The possible role of chromosome X variability in hypertensive familiarity

M. Ciccarelli, R. Finelli, N. Rivera, G. Santulli, R. Izzo, N. de Luca, F. Rozza, M. Ceccarelli, S. Pagnotta, F. Uliano, R. Tremigliozzi, G. Condorelli, V. Trimarco, G. Iaccarino

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Familiarity participates in the pathogenesis of hypertension, although only recently, whole genome studies have proposed regions of the human genome possibly involved in the transmission of the hypertensive phenotype. Although studies have mainly focused on autosome, hitherto the influence of sex on familial transmission of hypertension has not been considered. We analysed the database of the Campania Salute Network of Hypertension center of the Federico II University Hospital of Naples (Italy), using dichotomous variables for paternal and maternal familiarity and gender (male and female) of 12 504 hypertensive patients (6868 males and 5636 females) and 6352 controls (3484 males and 2868 females), totaling 18 856 subjects. In the hypertensive group, familiarity was present in 75% of cases with odds of 3.77 and in only 26% of the normotensives with odds of 0.94. The odds ratio (OR) indicated that familiarity increases the risk of developing hypertension by 2.91 (95% confidence interval (CI)=2.67–3.17, P

Original languageEnglish
JournalJournal of Human Hypertension
Publication statusAccepted/In press - Feb 25 2016

ASJC Scopus subject areas

  • Internal Medicine


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