The possible role of flavonoids in the prevention of diabetic complications

Roberto Testa, Anna Rita Bonfigli, Stefano Genovese, Valeria De Nigris, Antonio Ceriello

Research output: Contribution to journalArticle

Abstract

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.

Original languageEnglish
Article number310
JournalNutrients
Volume8
Issue number5
DOIs
Publication statusPublished - May 20 2016

Fingerprint

Diabetes Complications
Flavonoids
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
flavonoids
retinal diseases
peripheral nervous system diseases
Metabolic Networks and Pathways
kidney diseases
Lipid Metabolism
insulin resistance
lipid metabolism
cardiovascular diseases
Insulin Resistance
biochemical pathways
Oxidative Stress
oxidative stress
Cardiovascular Diseases
insulin
Animal Models

Keywords

  • Diabetic complications
  • Flavonoids
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Food Science

Cite this

The possible role of flavonoids in the prevention of diabetic complications. / Testa, Roberto; Bonfigli, Anna Rita; Genovese, Stefano; De Nigris, Valeria; Ceriello, Antonio.

In: Nutrients, Vol. 8, No. 5, 310, 20.05.2016.

Research output: Contribution to journalArticle

Testa, Roberto ; Bonfigli, Anna Rita ; Genovese, Stefano ; De Nigris, Valeria ; Ceriello, Antonio. / The possible role of flavonoids in the prevention of diabetic complications. In: Nutrients. 2016 ; Vol. 8, No. 5.
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