Abstract
Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
| Original language | English |
|---|---|
| Article number | 310 |
| Journal | Nutrients |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 20 2016 |
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Keywords
- Diabetic complications
- Flavonoids
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Food Science
Cite this
The possible role of flavonoids in the prevention of diabetic complications. / Testa, Roberto; Bonfigli, Anna Rita; Genovese, Stefano; De Nigris, Valeria; Ceriello, Antonio.
In: Nutrients, Vol. 8, No. 5, 310, 20.05.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The possible role of flavonoids in the prevention of diabetic complications
AU - Testa, Roberto
AU - Bonfigli, Anna Rita
AU - Genovese, Stefano
AU - De Nigris, Valeria
AU - Ceriello, Antonio
PY - 2016/5/20
Y1 - 2016/5/20
N2 - Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
AB - Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
KW - Diabetic complications
KW - Flavonoids
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84969670586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969670586&partnerID=8YFLogxK
U2 - 10.3390/nu8050310
DO - 10.3390/nu8050310
M3 - Article
VL - 8
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 310
ER -