The post-prandial state in Type 2 diabetes and endothelial dysfunction: Effects of insulin aspart

A. Ceriello, A. Cavarape, L. Martinelli, R. Da Ros, G. Marrat, L. Quagliaro, L. Piconi, R. Assaloni, E. Motz

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objective: Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods: Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1,2,4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results: Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P <0.04), and preserved flow-mediated vasodilation, which was decreased in the post-prandial state (39.4 ± 2.9 vs. 34.1 ± 2.2; P <0.01). Triglyceride and free fatty acid levels were not differentially affected by the treatment. In normal controls the meal did not affect flow-mediated vasodilation. Conclusion: This study shows that the post-prandial state is accompanied by endothelial dysfunction in Type 2 diabetic patients and that insulin aspart improved endothelial function.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalDiabetic Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Insulin Aspart
Type 2 Diabetes Mellitus
Meals
Vasodilation
Hyperglycemia
Nonesterified Fatty Acids
Triglycerides
Body Weight
Short-Acting Insulin
Insulin
Subcutaneous Injections
Area Under Curve
Blood Glucose

Keywords

  • Diabetic complications
  • Endothelial dysfunction
  • Free fatty acids
  • Insulin aspart
  • Post-prandial hyperglycaemia
  • Regular insulin
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

The post-prandial state in Type 2 diabetes and endothelial dysfunction : Effects of insulin aspart. / Ceriello, A.; Cavarape, A.; Martinelli, L.; Da Ros, R.; Marrat, G.; Quagliaro, L.; Piconi, L.; Assaloni, R.; Motz, E.

In: Diabetic Medicine, Vol. 21, No. 2, 02.2004, p. 171-175.

Research output: Contribution to journalArticle

Ceriello, A, Cavarape, A, Martinelli, L, Da Ros, R, Marrat, G, Quagliaro, L, Piconi, L, Assaloni, R & Motz, E 2004, 'The post-prandial state in Type 2 diabetes and endothelial dysfunction: Effects of insulin aspart', Diabetic Medicine, vol. 21, no. 2, pp. 171-175. https://doi.org/10.1111/j.1464-5491.2004.01101.x
Ceriello, A. ; Cavarape, A. ; Martinelli, L. ; Da Ros, R. ; Marrat, G. ; Quagliaro, L. ; Piconi, L. ; Assaloni, R. ; Motz, E. / The post-prandial state in Type 2 diabetes and endothelial dysfunction : Effects of insulin aspart. In: Diabetic Medicine. 2004 ; Vol. 21, No. 2. pp. 171-175.
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