Abstract
Objective: Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods: Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1,2,4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results: Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P <0.04), and preserved flow-mediated vasodilation, which was decreased in the post-prandial state (39.4 ± 2.9 vs. 34.1 ± 2.2; P <0.01). Triglyceride and free fatty acid levels were not differentially affected by the treatment. In normal controls the meal did not affect flow-mediated vasodilation. Conclusion: This study shows that the post-prandial state is accompanied by endothelial dysfunction in Type 2 diabetic patients and that insulin aspart improved endothelial function.
| Original language | English |
|---|---|
| Pages (from-to) | 171-175 |
| Number of pages | 5 |
| Journal | Diabetic Medicine |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2004 |
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Keywords
- Diabetic complications
- Endothelial dysfunction
- Free fatty acids
- Insulin aspart
- Post-prandial hyperglycaemia
- Regular insulin
- Triglycerides
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
The post-prandial state in Type 2 diabetes and endothelial dysfunction : Effects of insulin aspart. / Ceriello, A.; Cavarape, A.; Martinelli, L.; Da Ros, R.; Marrat, G.; Quagliaro, L.; Piconi, L.; Assaloni, R.; Motz, E.
In: Diabetic Medicine, Vol. 21, No. 2, 02.2004, p. 171-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The post-prandial state in Type 2 diabetes and endothelial dysfunction
T2 - Effects of insulin aspart
AU - Ceriello, A.
AU - Cavarape, A.
AU - Martinelli, L.
AU - Da Ros, R.
AU - Marrat, G.
AU - Quagliaro, L.
AU - Piconi, L.
AU - Assaloni, R.
AU - Motz, E.
PY - 2004/2
Y1 - 2004/2
N2 - Objective: Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods: Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1,2,4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results: Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P <0.04), and preserved flow-mediated vasodilation, which was decreased in the post-prandial state (39.4 ± 2.9 vs. 34.1 ± 2.2; P <0.01). Triglyceride and free fatty acid levels were not differentially affected by the treatment. In normal controls the meal did not affect flow-mediated vasodilation. Conclusion: This study shows that the post-prandial state is accompanied by endothelial dysfunction in Type 2 diabetic patients and that insulin aspart improved endothelial function.
AB - Objective: Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods: Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1,2,4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results: Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P <0.04), and preserved flow-mediated vasodilation, which was decreased in the post-prandial state (39.4 ± 2.9 vs. 34.1 ± 2.2; P <0.01). Triglyceride and free fatty acid levels were not differentially affected by the treatment. In normal controls the meal did not affect flow-mediated vasodilation. Conclusion: This study shows that the post-prandial state is accompanied by endothelial dysfunction in Type 2 diabetic patients and that insulin aspart improved endothelial function.
KW - Diabetic complications
KW - Endothelial dysfunction
KW - Free fatty acids
KW - Insulin aspart
KW - Post-prandial hyperglycaemia
KW - Regular insulin
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=1242292299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242292299&partnerID=8YFLogxK
U2 - 10.1111/j.1464-5491.2004.01101.x
DO - 10.1111/j.1464-5491.2004.01101.x
M3 - Article
C2 - 14984453
AN - SCOPUS:1242292299
VL - 21
SP - 171
EP - 175
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 2
ER -