The post-prandial state in Type 2 diabetes and endothelial dysfunction: Effects of insulin aspart

A. Ceriello, A. Cavarape, L. Martinelli, R. Da Ros, G. Marrat, L. Quagliaro, L. Piconi, R. Assaloni, E. Motz

Research output: Contribution to journalArticle

Abstract

Objective: Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods: Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1,2,4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results: Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P <0.04), and preserved flow-mediated vasodilation, which was decreased in the post-prandial state (39.4 ± 2.9 vs. 34.1 ± 2.2; P <0.01). Triglyceride and free fatty acid levels were not differentially affected by the treatment. In normal controls the meal did not affect flow-mediated vasodilation. Conclusion: This study shows that the post-prandial state is accompanied by endothelial dysfunction in Type 2 diabetic patients and that insulin aspart improved endothelial function.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalDiabetic Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Diabetic complications
  • Endothelial dysfunction
  • Free fatty acids
  • Insulin aspart
  • Post-prandial hyperglycaemia
  • Regular insulin
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint Dive into the research topics of 'The post-prandial state in Type 2 diabetes and endothelial dysfunction: Effects of insulin aspart'. Together they form a unique fingerprint.

  • Cite this

    Ceriello, A., Cavarape, A., Martinelli, L., Da Ros, R., Marrat, G., Quagliaro, L., Piconi, L., Assaloni, R., & Motz, E. (2004). The post-prandial state in Type 2 diabetes and endothelial dysfunction: Effects of insulin aspart. Diabetic Medicine, 21(2), 171-175. https://doi.org/10.1111/j.1464-5491.2004.01101.x