Il modello del siero postprandiale, un "tool" trascurato per le sperimentazioni in vitro di nutrienti

Translated title of the contribution: The postprandial serum: A neglected "tool" for nutritional studies

Francesco Piacenza, Marco Malavolta, Laura Costarelli, Robertina Giacconi, Andrea Basso, Eugenio Mocchegiani

Research output: Contribution to journalArticlepeer-review


Studies "in vitro" designed to highlight the properties and mechanisms of action of macro- and micronutrients in cellular models are particularly important to achieve knowledge in relatively short time and with reduced costs compared to studies "in vivo". However, the real exposure of our cells during supplementation with micronutrients may be far beyond the doses and the forms of the micronutrients used in the experiments "in vitro". To overcome this problem, "in vitro" treatments of cell lines using serum obtained from subjects under particular dietary interventions (i.e. caloric restriction) was attempted with success. However, large part of our life occur in the post-prandial status and the postprandial serum is enriched of the various components of the diet transformed by multitude physiological processes. Hence, in this brief review we will examine the potential and will propose as tool for nutritional studies a cellular models based on treatments with the post prandial serum in order to study the effects of particular dietary intervention or supplementation with micronutrients.

Translated title of the contributionThe postprandial serum: A neglected "tool" for nutritional studies
Original languageItalian
Pages (from-to)276-283
Number of pages8
JournalProgress in Nutrition
Issue number4
Publication statusPublished - Dec 1 2014

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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