The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis

Paola Scognamiglio, Giacomina Chiaradia, Gabriella De Carli, Massimo Giuliani, Claudio M. Mastroianni, Stefano Aviani Barbacci, Anna R. Buonomini, Susanna Grisetti, Alessandro Sampaolesi, Angela Corpolongo, Nicoletta Orchi, Vincenzo Puro, Giuseppe Ippolito, Enrico Girardi, E. Girardi, N. Orchi, C. Angeletti, R. Balzano, P. Elia, A. NavarraG. Nurra, A. Palummieri, L. Alba, A. Ammassari, A. Antinori, F. Baldini, R. Bellagamba, N. Bevilacqua, E. Boumis, M. R. Capobianchi, S. Cerilli, P. Chinello, A. Corpolongo, R. D'Arrigo, G. De Carli, [No Value] D'OffiziG., F. Forbici, F. M. Fusco, V. Galati, P. Ghirga, L. Giancola, C. Gori, S. Grisetti, F. N. Lauria, G. Liuzzi, P. Marconi, A. Mariano, P. Narciso, E. Nicastri, P. Noto, A. F. Palmieri, C. F. Perno, N. Petrosillo, R. Pisapia, S. Pittalis, V. Puro, A. Sampaolesi, P. Scognamiglio, M. R. Sciarrone, M. Selleri, C. Sias, S. Topino, V. Tozzi, L. Vincenzi, U. Visco Comandini, C. Vlassi, M. Zaccarelli, S. Zaniratti, V. Vullo, M. Falciano, M. Andreoni, L. Sarmati, A. R. Buonomini, A. Di Carlo, M. Giuliani, R. Brancatella, T. Maggi, F. Errico, A. De Filippis, R. Di Bacco, S. Schito, P. Gattari, L. Spizzichino, M. Francesconi, G. Pace, I. Gallo, E. Anzalone, C. M. Mastroianni, L. Tacconi, V. S. Mercurio, M. Lichtner, G. Natalini Raponi, A. Pitorri, A. Caterini, S. Aviani Barbacci

Research output: Contribution to journalArticle

Abstract

Background: The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrospective analysis among individuals diagnosed with HIV to assess whether a history of certain diseases prior to HIV diagnosis was associated with the chance of presenting late for care, and to estimate the proportion of individuals presenting late who could have been diagnosed earlier if tested when the indicator disease was diagnosed.Methods: We studied a large cohort of individuals newly diagnosed with HIV infection in 13 counselling and testing sites in the Lazio Region, Italy (01/01/2004-30/04/2009). Considered indicator diseases were: viral hepatitis infection (HBV/HCV), sexually transmitted infections, seborrhoeic dermatitis and tuberculosis. Logistic regression analysis was performed to estimate association of occurrence of at least one indicator disease with late HIV diagnosis.Results: In our analysis, the prevalence of late HIV diagnosis was 51.3% (890/1735). Individuals reporting at least one indicator disease before HIV diagnosis (29% of the study population) had a lower risk of late diagnosis (OR = 0.7; 95%CI: 0.5-0.8) compared to those who did not report a previous indicator disease. 52/890 (5.8%) late presenters were probably already infected at the time the indicator disease was diagnosed, a median of 22.6 months before HIV diagnosis.Conclusions: Our data suggest that testing for HIV following diagnosis of an indicator disease significantly decreases the probability of late HIV diagnosis. Moreover, for 5.5% of late HIV presenters, diagnosis could have been anticipated if they had been tested when an HIV indicator disease was diagnosed.However, this strategy for enhancing early HIV diagnosis needs to be complemented by client-centred interventions that aim to increase awareness in people who do not perceive themselves as being at risk for HIV.

Original languageEnglish
Article number473
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - Oct 10 2013

Keywords

  • HIV testing
  • Indicator diseases
  • Late diagnosis
  • Sexually transmitted infections

ASJC Scopus subject areas

  • Infectious Diseases

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