The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis

Paola Scognamiglio, Giacomina Chiaradia, Gabriella De Carli, Massimo Giuliani, Claudio M. Mastroianni, Stefano Aviani Barbacci, Anna R. Buonomini, Susanna Grisetti, Alessandro Sampaolesi, Angela Corpolongo, Nicoletta Orchi, Vincenzo Puro, Giuseppe Ippolito, Enrico Girardi, E. Girardi, N. Orchi, C. Angeletti, R. Balzano, P. Elia, A. NavarraG. Nurra, A. Palummieri, L. Alba, A. Ammassari, A. Antinori, F. Baldini, R. Bellagamba, N. Bevilacqua, E. Boumis, M. R. Capobianchi, S. Cerilli, P. Chinello, A. Corpolongo, R. D'Arrigo, G. De Carli, [No Value] D'OffiziG., F. Forbici, F. M. Fusco, V. Galati, P. Ghirga, L. Giancola, C. Gori, S. Grisetti, F. N. Lauria, G. Liuzzi, P. Marconi, A. Mariano, P. Narciso, E. Nicastri, P. Noto, A. F. Palmieri, C. F. Perno, N. Petrosillo, R. Pisapia, S. Pittalis, V. Puro, A. Sampaolesi, P. Scognamiglio, M. R. Sciarrone, M. Selleri, C. Sias, S. Topino, V. Tozzi, L. Vincenzi, U. Visco Comandini, C. Vlassi, M. Zaccarelli, S. Zaniratti, V. Vullo, M. Falciano, M. Andreoni, L. Sarmati, A. R. Buonomini, A. Di Carlo, M. Giuliani, R. Brancatella, T. Maggi, F. Errico, A. De Filippis, R. Di Bacco, S. Schito, P. Gattari, L. Spizzichino, M. Francesconi, G. Pace, I. Gallo, E. Anzalone, C. M. Mastroianni, L. Tacconi, V. S. Mercurio, M. Lichtner, G. Natalini Raponi, A. Pitorri, A. Caterini, S. Aviani Barbacci

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrospective analysis among individuals diagnosed with HIV to assess whether a history of certain diseases prior to HIV diagnosis was associated with the chance of presenting late for care, and to estimate the proportion of individuals presenting late who could have been diagnosed earlier if tested when the indicator disease was diagnosed.Methods: We studied a large cohort of individuals newly diagnosed with HIV infection in 13 counselling and testing sites in the Lazio Region, Italy (01/01/2004-30/04/2009). Considered indicator diseases were: viral hepatitis infection (HBV/HCV), sexually transmitted infections, seborrhoeic dermatitis and tuberculosis. Logistic regression analysis was performed to estimate association of occurrence of at least one indicator disease with late HIV diagnosis.Results: In our analysis, the prevalence of late HIV diagnosis was 51.3% (890/1735). Individuals reporting at least one indicator disease before HIV diagnosis (29% of the study population) had a lower risk of late diagnosis (OR = 0.7; 95%CI: 0.5-0.8) compared to those who did not report a previous indicator disease. 52/890 (5.8%) late presenters were probably already infected at the time the indicator disease was diagnosed, a median of 22.6 months before HIV diagnosis.Conclusions: Our data suggest that testing for HIV following diagnosis of an indicator disease significantly decreases the probability of late HIV diagnosis. Moreover, for 5.5% of late HIV presenters, diagnosis could have been anticipated if they had been tested when an HIV indicator disease was diagnosed.However, this strategy for enhancing early HIV diagnosis needs to be complemented by client-centred interventions that aim to increase awareness in people who do not perceive themselves as being at risk for HIV.

Original languageEnglish
Article number473
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - Oct 10 2013

Fingerprint

Delayed Diagnosis
HIV
Dermatitis
Virus Diseases
Sexually Transmitted Diseases
Italy
Hepatitis
HIV Infections
Counseling
Early Diagnosis
Tuberculosis

Keywords

  • HIV testing
  • Indicator diseases
  • Late diagnosis
  • Sexually transmitted infections

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis. / Scognamiglio, Paola; Chiaradia, Giacomina; De Carli, Gabriella; Giuliani, Massimo; Mastroianni, Claudio M.; Aviani Barbacci, Stefano; Buonomini, Anna R.; Grisetti, Susanna; Sampaolesi, Alessandro; Corpolongo, Angela; Orchi, Nicoletta; Puro, Vincenzo; Ippolito, Giuseppe; Girardi, Enrico; Girardi, E.; Orchi, N.; Angeletti, C.; Balzano, R.; Elia, P.; Navarra, A.; Nurra, G.; Palummieri, A.; Alba, L.; Ammassari, A.; Antinori, A.; Baldini, F.; Bellagamba, R.; Bevilacqua, N.; Boumis, E.; Capobianchi, M. R.; Cerilli, S.; Chinello, P.; Corpolongo, A.; D'Arrigo, R.; De Carli, G.; D'OffiziG., [No Value]; Forbici, F.; Fusco, F. M.; Galati, V.; Ghirga, P.; Giancola, L.; Gori, C.; Grisetti, S.; Lauria, F. N.; Liuzzi, G.; Marconi, P.; Mariano, A.; Narciso, P.; Nicastri, E.; Noto, P.; Palmieri, A. F.; Perno, C. F.; Petrosillo, N.; Pisapia, R.; Pittalis, S.; Puro, V.; Sampaolesi, A.; Scognamiglio, P.; Sciarrone, M. R.; Selleri, M.; Sias, C.; Topino, S.; Tozzi, V.; Vincenzi, L.; Visco Comandini, U.; Vlassi, C.; Zaccarelli, M.; Zaniratti, S.; Vullo, V.; Falciano, M.; Andreoni, M.; Sarmati, L.; Buonomini, A. R.; Di Carlo, A.; Giuliani, M.; Brancatella, R.; Maggi, T.; Errico, F.; De Filippis, A.; Di Bacco, R.; Schito, S.; Gattari, P.; Spizzichino, L.; Francesconi, M.; Pace, G.; Gallo, I.; Anzalone, E.; Mastroianni, C. M.; Tacconi, L.; Mercurio, V. S.; Lichtner, M.; Natalini Raponi, G.; Pitorri, A.; Caterini, A.; Aviani Barbacci, S.

In: BMC Infectious Diseases, Vol. 13, No. 1, 473, 10.10.2013.

Research output: Contribution to journalArticle

Scognamiglio, P, Chiaradia, G, De Carli, G, Giuliani, M, Mastroianni, CM, Aviani Barbacci, S, Buonomini, AR, Grisetti, S, Sampaolesi, A, Corpolongo, A, Orchi, N, Puro, V, Ippolito, G, Girardi, E, Girardi, E, Orchi, N, Angeletti, C, Balzano, R, Elia, P, Navarra, A, Nurra, G, Palummieri, A, Alba, L, Ammassari, A, Antinori, A, Baldini, F, Bellagamba, R, Bevilacqua, N, Boumis, E, Capobianchi, MR, Cerilli, S, Chinello, P, Corpolongo, A, D'Arrigo, R, De Carli, G, D'OffiziG., NV, Forbici, F, Fusco, FM, Galati, V, Ghirga, P, Giancola, L, Gori, C, Grisetti, S, Lauria, FN, Liuzzi, G, Marconi, P, Mariano, A, Narciso, P, Nicastri, E, Noto, P, Palmieri, AF, Perno, CF, Petrosillo, N, Pisapia, R, Pittalis, S, Puro, V, Sampaolesi, A, Scognamiglio, P, Sciarrone, MR, Selleri, M, Sias, C, Topino, S, Tozzi, V, Vincenzi, L, Visco Comandini, U, Vlassi, C, Zaccarelli, M, Zaniratti, S, Vullo, V, Falciano, M, Andreoni, M, Sarmati, L, Buonomini, AR, Di Carlo, A, Giuliani, M, Brancatella, R, Maggi, T, Errico, F, De Filippis, A, Di Bacco, R, Schito, S, Gattari, P, Spizzichino, L, Francesconi, M, Pace, G, Gallo, I, Anzalone, E, Mastroianni, CM, Tacconi, L, Mercurio, VS, Lichtner, M, Natalini Raponi, G, Pitorri, A, Caterini, A & Aviani Barbacci, S 2013, 'The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis', BMC Infectious Diseases, vol. 13, no. 1, 473. https://doi.org/10.1186/1471-2334-13-473
Scognamiglio, Paola ; Chiaradia, Giacomina ; De Carli, Gabriella ; Giuliani, Massimo ; Mastroianni, Claudio M. ; Aviani Barbacci, Stefano ; Buonomini, Anna R. ; Grisetti, Susanna ; Sampaolesi, Alessandro ; Corpolongo, Angela ; Orchi, Nicoletta ; Puro, Vincenzo ; Ippolito, Giuseppe ; Girardi, Enrico ; Girardi, E. ; Orchi, N. ; Angeletti, C. ; Balzano, R. ; Elia, P. ; Navarra, A. ; Nurra, G. ; Palummieri, A. ; Alba, L. ; Ammassari, A. ; Antinori, A. ; Baldini, F. ; Bellagamba, R. ; Bevilacqua, N. ; Boumis, E. ; Capobianchi, M. R. ; Cerilli, S. ; Chinello, P. ; Corpolongo, A. ; D'Arrigo, R. ; De Carli, G. ; D'OffiziG., [No Value] ; Forbici, F. ; Fusco, F. M. ; Galati, V. ; Ghirga, P. ; Giancola, L. ; Gori, C. ; Grisetti, S. ; Lauria, F. N. ; Liuzzi, G. ; Marconi, P. ; Mariano, A. ; Narciso, P. ; Nicastri, E. ; Noto, P. ; Palmieri, A. F. ; Perno, C. F. ; Petrosillo, N. ; Pisapia, R. ; Pittalis, S. ; Puro, V. ; Sampaolesi, A. ; Scognamiglio, P. ; Sciarrone, M. R. ; Selleri, M. ; Sias, C. ; Topino, S. ; Tozzi, V. ; Vincenzi, L. ; Visco Comandini, U. ; Vlassi, C. ; Zaccarelli, M. ; Zaniratti, S. ; Vullo, V. ; Falciano, M. ; Andreoni, M. ; Sarmati, L. ; Buonomini, A. R. ; Di Carlo, A. ; Giuliani, M. ; Brancatella, R. ; Maggi, T. ; Errico, F. ; De Filippis, A. ; Di Bacco, R. ; Schito, S. ; Gattari, P. ; Spizzichino, L. ; Francesconi, M. ; Pace, G. ; Gallo, I. ; Anzalone, E. ; Mastroianni, C. M. ; Tacconi, L. ; Mercurio, V. S. ; Lichtner, M. ; Natalini Raponi, G. ; Pitorri, A. ; Caterini, A. ; Aviani Barbacci, S. / The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis. In: BMC Infectious Diseases. 2013 ; Vol. 13, No. 1.
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abstract = "Background: The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrospective analysis among individuals diagnosed with HIV to assess whether a history of certain diseases prior to HIV diagnosis was associated with the chance of presenting late for care, and to estimate the proportion of individuals presenting late who could have been diagnosed earlier if tested when the indicator disease was diagnosed.Methods: We studied a large cohort of individuals newly diagnosed with HIV infection in 13 counselling and testing sites in the Lazio Region, Italy (01/01/2004-30/04/2009). Considered indicator diseases were: viral hepatitis infection (HBV/HCV), sexually transmitted infections, seborrhoeic dermatitis and tuberculosis. Logistic regression analysis was performed to estimate association of occurrence of at least one indicator disease with late HIV diagnosis.Results: In our analysis, the prevalence of late HIV diagnosis was 51.3{\%} (890/1735). Individuals reporting at least one indicator disease before HIV diagnosis (29{\%} of the study population) had a lower risk of late diagnosis (OR = 0.7; 95{\%}CI: 0.5-0.8) compared to those who did not report a previous indicator disease. 52/890 (5.8{\%}) late presenters were probably already infected at the time the indicator disease was diagnosed, a median of 22.6 months before HIV diagnosis.Conclusions: Our data suggest that testing for HIV following diagnosis of an indicator disease significantly decreases the probability of late HIV diagnosis. Moreover, for 5.5{\%} of late HIV presenters, diagnosis could have been anticipated if they had been tested when an HIV indicator disease was diagnosed.However, this strategy for enhancing early HIV diagnosis needs to be complemented by client-centred interventions that aim to increase awareness in people who do not perceive themselves as being at risk for HIV.",
keywords = "HIV testing, Indicator diseases, Late diagnosis, Sexually transmitted infections",
author = "Paola Scognamiglio and Giacomina Chiaradia and {De Carli}, Gabriella and Massimo Giuliani and Mastroianni, {Claudio M.} and {Aviani Barbacci}, Stefano and Buonomini, {Anna R.} and Susanna Grisetti and Alessandro Sampaolesi and Angela Corpolongo and Nicoletta Orchi and Vincenzo Puro and Giuseppe Ippolito and Enrico Girardi and E. Girardi and N. Orchi and C. Angeletti and R. Balzano and P. Elia and A. Navarra and G. Nurra and A. Palummieri and L. Alba and A. Ammassari and A. Antinori and F. Baldini and R. Bellagamba and N. Bevilacqua and E. Boumis and Capobianchi, {M. R.} and S. Cerilli and P. Chinello and A. Corpolongo and R. D'Arrigo and {De Carli}, G. and D'OffiziG., {[No Value]} and F. Forbici and Fusco, {F. M.} and V. Galati and P. Ghirga and L. Giancola and C. Gori and S. Grisetti and Lauria, {F. N.} and G. Liuzzi and P. Marconi and A. Mariano and P. Narciso and E. Nicastri and P. Noto and Palmieri, {A. F.} and Perno, {C. F.} and N. Petrosillo and R. Pisapia and S. Pittalis and V. Puro and A. Sampaolesi and P. Scognamiglio and Sciarrone, {M. R.} and M. Selleri and C. Sias and S. Topino and V. Tozzi and L. Vincenzi and {Visco Comandini}, U. and C. Vlassi and M. Zaccarelli and S. Zaniratti and V. Vullo and M. Falciano and M. Andreoni and L. Sarmati and Buonomini, {A. R.} and {Di Carlo}, A. and M. Giuliani and R. Brancatella and T. Maggi and F. Errico and {De Filippis}, A. and {Di Bacco}, R. and S. Schito and P. Gattari and L. Spizzichino and M. Francesconi and G. Pace and I. Gallo and E. Anzalone and Mastroianni, {C. M.} and L. Tacconi and Mercurio, {V. S.} and M. Lichtner and {Natalini Raponi}, G. and A. Pitorri and A. Caterini and {Aviani Barbacci}, S.",
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TY - JOUR

T1 - The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis

AU - Scognamiglio, Paola

AU - Chiaradia, Giacomina

AU - De Carli, Gabriella

AU - Giuliani, Massimo

AU - Mastroianni, Claudio M.

AU - Aviani Barbacci, Stefano

AU - Buonomini, Anna R.

AU - Grisetti, Susanna

AU - Sampaolesi, Alessandro

AU - Corpolongo, Angela

AU - Orchi, Nicoletta

AU - Puro, Vincenzo

AU - Ippolito, Giuseppe

AU - Girardi, Enrico

AU - Girardi, E.

AU - Orchi, N.

AU - Angeletti, C.

AU - Balzano, R.

AU - Elia, P.

AU - Navarra, A.

AU - Nurra, G.

AU - Palummieri, A.

AU - Alba, L.

AU - Ammassari, A.

AU - Antinori, A.

AU - Baldini, F.

AU - Bellagamba, R.

AU - Bevilacqua, N.

AU - Boumis, E.

AU - Capobianchi, M. R.

AU - Cerilli, S.

AU - Chinello, P.

AU - Corpolongo, A.

AU - D'Arrigo, R.

AU - De Carli, G.

AU - D'OffiziG., [No Value]

AU - Forbici, F.

AU - Fusco, F. M.

AU - Galati, V.

AU - Ghirga, P.

AU - Giancola, L.

AU - Gori, C.

AU - Grisetti, S.

AU - Lauria, F. N.

AU - Liuzzi, G.

AU - Marconi, P.

AU - Mariano, A.

AU - Narciso, P.

AU - Nicastri, E.

AU - Noto, P.

AU - Palmieri, A. F.

AU - Perno, C. F.

AU - Petrosillo, N.

AU - Pisapia, R.

AU - Pittalis, S.

AU - Puro, V.

AU - Sampaolesi, A.

AU - Scognamiglio, P.

AU - Sciarrone, M. R.

AU - Selleri, M.

AU - Sias, C.

AU - Topino, S.

AU - Tozzi, V.

AU - Vincenzi, L.

AU - Visco Comandini, U.

AU - Vlassi, C.

AU - Zaccarelli, M.

AU - Zaniratti, S.

AU - Vullo, V.

AU - Falciano, M.

AU - Andreoni, M.

AU - Sarmati, L.

AU - Buonomini, A. R.

AU - Di Carlo, A.

AU - Giuliani, M.

AU - Brancatella, R.

AU - Maggi, T.

AU - Errico, F.

AU - De Filippis, A.

AU - Di Bacco, R.

AU - Schito, S.

AU - Gattari, P.

AU - Spizzichino, L.

AU - Francesconi, M.

AU - Pace, G.

AU - Gallo, I.

AU - Anzalone, E.

AU - Mastroianni, C. M.

AU - Tacconi, L.

AU - Mercurio, V. S.

AU - Lichtner, M.

AU - Natalini Raponi, G.

AU - Pitorri, A.

AU - Caterini, A.

AU - Aviani Barbacci, S.

PY - 2013/10/10

Y1 - 2013/10/10

N2 - Background: The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrospective analysis among individuals diagnosed with HIV to assess whether a history of certain diseases prior to HIV diagnosis was associated with the chance of presenting late for care, and to estimate the proportion of individuals presenting late who could have been diagnosed earlier if tested when the indicator disease was diagnosed.Methods: We studied a large cohort of individuals newly diagnosed with HIV infection in 13 counselling and testing sites in the Lazio Region, Italy (01/01/2004-30/04/2009). Considered indicator diseases were: viral hepatitis infection (HBV/HCV), sexually transmitted infections, seborrhoeic dermatitis and tuberculosis. Logistic regression analysis was performed to estimate association of occurrence of at least one indicator disease with late HIV diagnosis.Results: In our analysis, the prevalence of late HIV diagnosis was 51.3% (890/1735). Individuals reporting at least one indicator disease before HIV diagnosis (29% of the study population) had a lower risk of late diagnosis (OR = 0.7; 95%CI: 0.5-0.8) compared to those who did not report a previous indicator disease. 52/890 (5.8%) late presenters were probably already infected at the time the indicator disease was diagnosed, a median of 22.6 months before HIV diagnosis.Conclusions: Our data suggest that testing for HIV following diagnosis of an indicator disease significantly decreases the probability of late HIV diagnosis. Moreover, for 5.5% of late HIV presenters, diagnosis could have been anticipated if they had been tested when an HIV indicator disease was diagnosed.However, this strategy for enhancing early HIV diagnosis needs to be complemented by client-centred interventions that aim to increase awareness in people who do not perceive themselves as being at risk for HIV.

AB - Background: The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrospective analysis among individuals diagnosed with HIV to assess whether a history of certain diseases prior to HIV diagnosis was associated with the chance of presenting late for care, and to estimate the proportion of individuals presenting late who could have been diagnosed earlier if tested when the indicator disease was diagnosed.Methods: We studied a large cohort of individuals newly diagnosed with HIV infection in 13 counselling and testing sites in the Lazio Region, Italy (01/01/2004-30/04/2009). Considered indicator diseases were: viral hepatitis infection (HBV/HCV), sexually transmitted infections, seborrhoeic dermatitis and tuberculosis. Logistic regression analysis was performed to estimate association of occurrence of at least one indicator disease with late HIV diagnosis.Results: In our analysis, the prevalence of late HIV diagnosis was 51.3% (890/1735). Individuals reporting at least one indicator disease before HIV diagnosis (29% of the study population) had a lower risk of late diagnosis (OR = 0.7; 95%CI: 0.5-0.8) compared to those who did not report a previous indicator disease. 52/890 (5.8%) late presenters were probably already infected at the time the indicator disease was diagnosed, a median of 22.6 months before HIV diagnosis.Conclusions: Our data suggest that testing for HIV following diagnosis of an indicator disease significantly decreases the probability of late HIV diagnosis. Moreover, for 5.5% of late HIV presenters, diagnosis could have been anticipated if they had been tested when an HIV indicator disease was diagnosed.However, this strategy for enhancing early HIV diagnosis needs to be complemented by client-centred interventions that aim to increase awareness in people who do not perceive themselves as being at risk for HIV.

KW - HIV testing

KW - Indicator diseases

KW - Late diagnosis

KW - Sexually transmitted infections

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UR - http://www.scopus.com/inward/citedby.url?scp=84885141724&partnerID=8YFLogxK

U2 - 10.1186/1471-2334-13-473

DO - 10.1186/1471-2334-13-473

M3 - Article

C2 - 24112129

AN - SCOPUS:84885141724

VL - 13

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

IS - 1

M1 - 473

ER -