The potential role of glutamate in the current diabetes epidemic

Alberto M. Davalli, Carla Perego, Franco B. Folli

Research output: Contribution to journalArticlepeer-review


In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the "accelerator hypothesis" and could partially explain the rising frequency of T1D and T2D.

Original languageEnglish
Pages (from-to)167-183
Number of pages17
JournalActa Diabetologica
Issue number3
Publication statusPublished - Jun 2012


  • Diabetes
  • Glutamate toxicity
  • l-Glutamic acid
  • Monosodium glutamate
  • Obesity
  • Pancreatic β-cells

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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