The potential role of lonidamine (LND) in the treatment of malignant glioma - Phase II study

Carmine M. Carapella; Marco G. Paggi; Fabio Cattani; Giovanni B. Ciottoli; Aristide Floridi; Bruno Iandolo; Laura Raus; Antonio Riccio; Antonio Caputo

doi:10.1007/BF00149384

The potential role of lonidamine (LND) in the treatment of malignant glioma - Phase II study

Carmine M. Carapella, Marco G. Paggi, Fabio Cattani, Giovanni B. Ciottoli, Aristide Floridi, Bruno Iandolo, Laura Raus, Antonio Riccio, Antonio Caputo

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Up-to-date unsatisfactory results obtained in multimodality treatments of malignant glioma have prompted the research of new therapeutic modalities with 'unconventional' modes of action. Lonidamine (LND) is a drug which reduces aerobic glycolytic activity in both human and experimental tumors. This effect mainly depends on the inhibition of mitochondrially-bound hexokinase (HK) which is present in large amounts in malignant cells. A Phase II study was conducted on patients with recurrent glioma; 12 patients were admitted to the study. Clinical side effects were moderate, necessitating a reduction of the dosage in only 1 case. The objective results were evaluated according to the indications of Levin. 2 responders and 3 cases of stable disease were observed out of 10 evaluable patients. The potential value of this new drug is discussed.

Original language	English
Pages (from-to)	103-108
Number of pages	6
Journal	Journal of Neuro-Oncology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF00149384
Publication status	Published - May 1989

Keywords

brain tumor metabolism
Lonidamine
malignant glioma

ASJC Scopus subject areas

Neuroscience(all)
Oncology
Clinical Neurology
Cancer Research

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10.1007/BF00149384

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The potential role of lonidamine (LND) in the treatment of malignant glioma - Phase II study. / Carapella, Carmine M.; Paggi, Marco G.; Cattani, Fabio; Ciottoli, Giovanni B.; Floridi, Aristide; Iandolo, Bruno; Raus, Laura; Riccio, Antonio; Caputo, Antonio.

In: Journal of Neuro-Oncology, Vol. 7, No. 1, 05.1989, p. 103-108.

Research output: Contribution to journal › Article › peer-review

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abstract = "Up-to-date unsatisfactory results obtained in multimodality treatments of malignant glioma have prompted the research of new therapeutic modalities with 'unconventional' modes of action. Lonidamine (LND) is a drug which reduces aerobic glycolytic activity in both human and experimental tumors. This effect mainly depends on the inhibition of mitochondrially-bound hexokinase (HK) which is present in large amounts in malignant cells. A Phase II study was conducted on patients with recurrent glioma; 12 patients were admitted to the study. Clinical side effects were moderate, necessitating a reduction of the dosage in only 1 case. The objective results were evaluated according to the indications of Levin. 2 responders and 3 cases of stable disease were observed out of 10 evaluable patients. The potential value of this new drug is discussed.",

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AU - Ciottoli, Giovanni B.

AU - Floridi, Aristide

AU - Iandolo, Bruno

AU - Raus, Laura

AU - Riccio, Antonio

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The potential role of lonidamine (LND) in the treatment of malignant glioma - Phase II study

Abstract

Keywords

ASJC Scopus subject areas

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