The potential role of vascular endothelial growth factor-A in IBD pathogenesis

Research output: Contribution to journalArticle

Abstract

It is now well established that angiogenesis plays a major role in many chronic inflammatory diseases including IBD. Vascular endothelial growth factor-A (VEGF-A), which is a widely studied pro-angiogenic mediator, is thought to play a key pathogenic role in IBD by promoting pathological angiogenesis and through its pro-inflammatory activities. Due to both its angiogenic and inflammatory action in chronic inflammation, VEGF-A has been identified as a possible therapeutic target, and recent experiments manipulating its expression have given rise to significant amelioration of colitis in murine models.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalInflammatory Bowel Disease Monitor
Volume9
Issue number3
Publication statusPublished - 2009

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Vascular Endothelial Growth Factor A
Pathologic Neovascularization
Colitis
Chronic Disease
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "It is now well established that angiogenesis plays a major role in many chronic inflammatory diseases including IBD. Vascular endothelial growth factor-A (VEGF-A), which is a widely studied pro-angiogenic mediator, is thought to play a key pathogenic role in IBD by promoting pathological angiogenesis and through its pro-inflammatory activities. Due to both its angiogenic and inflammatory action in chronic inflammation, VEGF-A has been identified as a possible therapeutic target, and recent experiments manipulating its expression have given rise to significant amelioration of colitis in murine models.",
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