It is now well established that angiogenesis plays a major role in many chronic inflammatory diseases including IBD. Vascular endothelial growth factor-A (VEGF-A), which is a widely studied pro-angiogenic mediator, is thought to play a key pathogenic role in IBD by promoting pathological angiogenesis and through its pro-inflammatory activities. Due to both its angiogenic and inflammatory action in chronic inflammation, VEGF-A has been identified as a possible therapeutic target, and recent experiments manipulating its expression have given rise to significant amelioration of colitis in murine models.
|Number of pages||5|
|Journal||Inflammatory Bowel Disease Monitor|
|Publication status||Published - 2009|
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