The potential use of urine cell free DNA as a marker for cancer

Samanta Salvi, Filippo Martignano, Chiara Molinari, Giorgia Gurioli, Daniele Calistri, Ugo De Giorgi, Vincenza Conteduca, Valentina Casadio

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Although the role of circulating cell free DNA in cancer has been widely demonstrated, less is known about the role of urine cell free DNA (UcfDNA). UcfDNA can serve as a ‘liquid biopsy’ for urological and non-urological tumors, as it carries information on DNA from cells exfoliated in urine and from circulation. Areas covered: We review the studies on UcfDNA as a source of biomarkers for cancer, focusing on the new techniques and the differences between urological and non-urological tumors. We searched Pubmed for articles published between 1998 and 2016 with the following key words and phrases: ‘urine’ and ‘cell free DNA’ or ‘liquid biopsy’ or ‘cancer’. Expert commentary: Despite the few papers published on this topic, UcfDNA is an important component of ‘liquid biopsy’, a useful and non-invasive tool for cancer diagnosis, prognosis and treatment monitoring, containing a wide range of genetic information.

Original languageEnglish
Pages (from-to)1283-1290
Number of pages8
JournalExpert Review of Molecular Diagnostics
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • cancer
  • cell free DNA
  • liquid biopsy
  • markers
  • Urine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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