The potentials and limitations of neuro-biomarkers as predictors of outcome in neonates with birth asphyxia

Angela Satriano, Francesca Pluchinotta, Francesca Gazzolo, Laura Serpero, Diego Gazzolo

Research output: Contribution to journalReview articlepeer-review

Abstract

Perinatal asphyxia and its complication, hypoxic-ischemic encephalopathy, are still among the major causes of perinatal mortality and morbidity. Despite accurate standard postnatal monitoring procedures, the post-insult period is crucial because at a time when radiologic pictures are still silent, brain damage may already be at a subclinical stage. Against this background, the measurement of quantitative parameters, such as constituents of nervous tissue, that are able to detect subclinical lesions at a stage when routine brain monitoring procedures are still silent, could be particularly useful. Therefore, in the present review we report the potentials and limitations of biomarkers in predicting outcome in neonates complicated by perinatal asphyxia.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalEarly Human Development
Volume105
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Asphyxia Neonatorum/blood
  • Biomarkers/blood
  • Central Nervous System/metabolism
  • Humans
  • Infant, Newborn

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