TY - JOUR
T1 - The potentials and limitations of neuro-biomarkers as predictors of outcome in neonates with birth asphyxia
AU - Satriano, Angela
AU - Pluchinotta, Francesca
AU - Gazzolo, Francesca
AU - Serpero, Laura
AU - Gazzolo, Diego
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Perinatal asphyxia and its complication, hypoxic-ischemic encephalopathy, are still among the major causes of perinatal mortality and morbidity. Despite accurate standard postnatal monitoring procedures, the post-insult period is crucial because at a time when radiologic pictures are still silent, brain damage may already be at a subclinical stage. Against this background, the measurement of quantitative parameters, such as constituents of nervous tissue, that are able to detect subclinical lesions at a stage when routine brain monitoring procedures are still silent, could be particularly useful. Therefore, in the present review we report the potentials and limitations of biomarkers in predicting outcome in neonates complicated by perinatal asphyxia.
AB - Perinatal asphyxia and its complication, hypoxic-ischemic encephalopathy, are still among the major causes of perinatal mortality and morbidity. Despite accurate standard postnatal monitoring procedures, the post-insult period is crucial because at a time when radiologic pictures are still silent, brain damage may already be at a subclinical stage. Against this background, the measurement of quantitative parameters, such as constituents of nervous tissue, that are able to detect subclinical lesions at a stage when routine brain monitoring procedures are still silent, could be particularly useful. Therefore, in the present review we report the potentials and limitations of biomarkers in predicting outcome in neonates complicated by perinatal asphyxia.
KW - Asphyxia Neonatorum/blood
KW - Biomarkers/blood
KW - Central Nervous System/metabolism
KW - Humans
KW - Infant, Newborn
U2 - 10.1016/j.earlhumdev.2016.12.005
DO - 10.1016/j.earlhumdev.2016.12.005
M3 - Review article
C2 - 27993431
VL - 105
SP - 63
EP - 67
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
ER -