The power of systematic genealogical study in familial Alzheimer disease

A. C. Bruni, M. P. Montesi, I. Rainero, L. Ferini-Strambi, F. Macciardi, L. Pinessi, G. Gei, D. Fragiacomo, L. Bergamini

Research output: Contribution to journalArticle

Abstract

Several kindreds (N,C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 1993

Keywords

  • Familial Alzheimer disease
  • founder effect
  • genealogical method

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The power of systematic genealogical study in familial Alzheimer disease'. Together they form a unique fingerprint.

  • Cite this

    Bruni, A. C., Montesi, M. P., Rainero, I., Ferini-Strambi, L., Macciardi, F., Pinessi, L., Gei, G., Fragiacomo, D., & Bergamini, L. (1993). The power of systematic genealogical study in familial Alzheimer disease. Italian Journal of Neurological Sciences, 14(3), 239-244. https://doi.org/10.1007/BF02335665