The power of systematic genealogical study in familial Alzheimer disease

A. C. Bruni; M. P. Montesi; I. Rainero; L. Ferini-Strambi; F. Macciardi; L. Pinessi; G. Gei; D. Fragiacomo; L. Bergamini

doi:10.1007/BF02335665

The power of systematic genealogical study in familial Alzheimer disease

A. C. Bruni, M. P. Montesi, I. Rainero, L. Ferini-Strambi, F. Macciardi, L. Pinessi, G. Gei, D. Fragiacomo, L. Bergamini

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Several kindreds (N,C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.

Original language	English
Pages (from-to)	239-244
Number of pages	6
Journal	Italian Journal of Neurological Sciences
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/BF02335665
Publication status	Published - Apr 1993

Keywords

Familial Alzheimer disease
founder effect
genealogical method

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/BF02335665

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abstract = "Several kindreds (N,C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.",

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AU - Bruni, A. C.

AU - Montesi, M. P.

AU - Rainero, I.

AU - Ferini-Strambi, L.

AU - Macciardi, F.

AU - Pinessi, L.

AU - Gei, G.

AU - Fragiacomo, D.

AU - Bergamini, L.

PY - 1993/4

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KW - founder effect

KW - genealogical method

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The power of systematic genealogical study in familial Alzheimer disease

Abstract

Keywords

ASJC Scopus subject areas

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