The power of systematic genealogical study in familial Alzheimer disease

A. C. Bruni, M. P. Montesi, I. Rainero, L. Ferini-Strambi, F. Macciardi, L. Pinessi, G. Gei, D. Fragiacomo, L. Bergamini

Research output: Contribution to journalArticlepeer-review


Several kindreds (N,C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number3
Publication statusPublished - Apr 1993


  • Familial Alzheimer disease
  • founder effect
  • genealogical method

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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