The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility in an Iranian cohort

H. Ghaedi, M. Tabasinezhad, B. Alipoor, F. Shokri, A. Movafagh, R. Mirfakhraie, M. D. Omrani, A. Masotti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The study was aimed at investigating the association between hsa-mir-27a polymorphism rs895819 (T/C) and type 2 diabetes mellitus (T2DM) susceptibility in a large Iranian cohort. Methods: In this case–control study, the investigated population consisted of T2DM patients (n = 204) and sex- and age-matched controls (n = 209). We used the polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) for genotyping. Results: We observed significant differences between T2DM patients and controls for weight (p = 0.002), BMI (p < 0.001), systolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.001), fasting plasma glucose (p < 0.001), triglyceride (p = 0.004) and LDL cholesterol (p = 0.051). Moreover, we found that genotype distributions were significantly different between groups (p < 0.05) and that the rs895819-C allele is more frequent in controls (p = 0.030, OR = 0.72, 95 % CI 0.53–0.97). Conclusion: Our study shows that rs895819 in hsa-mir-27a is associated with T2DM susceptibility and that the C allele conveyed a protective role against T2DM. Larger multicentric and specific functional studies will be necessary to obtain a deeper comprehension of the role of rs895819 and hsa-mir-27a and how they are involved in the development of diabetes.

Original languageEnglish
Pages (from-to)1187-1193
Number of pages7
JournalJournal of Endocrinological Investigation
Volume39
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • hsa-mir-27a
  • MicroRNA
  • Single nucleotide polymorphism
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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