The presence of J chain in mesangial immune deposits of IgA nephropathy.

U. Donini, S. Casanova, N. Zini, P. Zucchelli

Research output: Contribution to journalArticlepeer-review

Abstract

In order to identify polymeric IgA in the mesangial IgA deposits of 33 patients, the presence of J chains by a PAP method was investigated. In 9/27 cases of primary IgA nephropathy (PIgANP) and in 4/4 cases of Henoch-Schönlein glomerulonephritis (HSGN) J chains were absent. The remaining cases, two of them with IgA glomerulonephritis associated with alcoholic cirrhosis (ACIgAGN), were J-positive. The two groups, PIgANP J-positive and PIgANP J-negative, were compared according to clinical features. The only difference detected was the time length between the disease onset and the renal biopsy, being shorter in the negative group.

Original languageEnglish
Pages (from-to)655-662
Number of pages8
JournalProceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
Volume19
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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