The presence of rapid on-site evaluation did not increase the adequacy and diagnostic accuracy of endoscopic ultrasound-guided tissue acquisition of solid pancreatic lesions with core needle

Carlo Fabbri, Lorenzo Fuccio, Adele Fornelli, Filippo Antonini, Rosa Liotta, Leonardo Frazzoni, Alberto Larghi, Antonella Maimone, Silvia Paggi, Paolo Gusella, Luca Barresi, Anna Maria Polifemo, Elio Iovine, Giampiero Macarri, Vincenzo Cennamo, Ilaria Tarantino

Research output: Contribution to journalArticle

Abstract

Background: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. Methods: Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. Results: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 % in the group sampled with ROSE and 88.1 % in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 %, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 %, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 % of cases with and without ROSE, respectively (p = 0.143). Conclusion: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
DOIs
Publication statusPublished - Jan 2017

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Needles
Outcome Assessment (Health Care)
Tertiary Care Centers
Sensitivity and Specificity

Keywords

  • Endoscopic ultrasound
  • EUS
  • Fine-needle aspiration
  • Pancreatic cancer
  • Rapid on-site evaluation
  • ROSE

ASJC Scopus subject areas

  • Surgery

Cite this

The presence of rapid on-site evaluation did not increase the adequacy and diagnostic accuracy of endoscopic ultrasound-guided tissue acquisition of solid pancreatic lesions with core needle. / Fabbri, Carlo; Fuccio, Lorenzo; Fornelli, Adele; Antonini, Filippo; Liotta, Rosa; Frazzoni, Leonardo; Larghi, Alberto; Maimone, Antonella; Paggi, Silvia; Gusella, Paolo; Barresi, Luca; Polifemo, Anna Maria; Iovine, Elio; Macarri, Giampiero; Cennamo, Vincenzo; Tarantino, Ilaria.

In: Surgical Endoscopy and Other Interventional Techniques, 01.2017, p. 1-6.

Research output: Contribution to journalArticle

Fabbri, Carlo ; Fuccio, Lorenzo ; Fornelli, Adele ; Antonini, Filippo ; Liotta, Rosa ; Frazzoni, Leonardo ; Larghi, Alberto ; Maimone, Antonella ; Paggi, Silvia ; Gusella, Paolo ; Barresi, Luca ; Polifemo, Anna Maria ; Iovine, Elio ; Macarri, Giampiero ; Cennamo, Vincenzo ; Tarantino, Ilaria. / The presence of rapid on-site evaluation did not increase the adequacy and diagnostic accuracy of endoscopic ultrasound-guided tissue acquisition of solid pancreatic lesions with core needle. In: Surgical Endoscopy and Other Interventional Techniques. 2017 ; pp. 1-6.
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abstract = "Background: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. Methods: Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. Results: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 {\%} in the group sampled with ROSE and 88.1 {\%} in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 {\%}, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 {\%}, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 {\%} of cases with and without ROSE, respectively (p = 0.143). Conclusion: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.",
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author = "Carlo Fabbri and Lorenzo Fuccio and Adele Fornelli and Filippo Antonini and Rosa Liotta and Leonardo Frazzoni and Alberto Larghi and Antonella Maimone and Silvia Paggi and Paolo Gusella and Luca Barresi and Polifemo, {Anna Maria} and Elio Iovine and Giampiero Macarri and Vincenzo Cennamo and Ilaria Tarantino",
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T1 - The presence of rapid on-site evaluation did not increase the adequacy and diagnostic accuracy of endoscopic ultrasound-guided tissue acquisition of solid pancreatic lesions with core needle

AU - Fabbri, Carlo

AU - Fuccio, Lorenzo

AU - Fornelli, Adele

AU - Antonini, Filippo

AU - Liotta, Rosa

AU - Frazzoni, Leonardo

AU - Larghi, Alberto

AU - Maimone, Antonella

AU - Paggi, Silvia

AU - Gusella, Paolo

AU - Barresi, Luca

AU - Polifemo, Anna Maria

AU - Iovine, Elio

AU - Macarri, Giampiero

AU - Cennamo, Vincenzo

AU - Tarantino, Ilaria

PY - 2017/1

Y1 - 2017/1

N2 - Background: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. Methods: Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. Results: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 % in the group sampled with ROSE and 88.1 % in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 %, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 %, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 % of cases with and without ROSE, respectively (p = 0.143). Conclusion: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.

AB - Background: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. Methods: Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. Results: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 % in the group sampled with ROSE and 88.1 % in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 %, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 %, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 % of cases with and without ROSE, respectively (p = 0.143). Conclusion: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.

KW - Endoscopic ultrasound

KW - EUS

KW - Fine-needle aspiration

KW - Pancreatic cancer

KW - Rapid on-site evaluation

KW - ROSE

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