The Presence of Uveitis Is Associated with a Sustained Response to the Interleukin (IL)-1 Inhibitors Anakinra and Canakinumab in Behçet's Disease

Claudia Fabiani, Antonio Vitale, Donato Rigante, Giacomo Emmi, Giuseppe Lopalco, Gerardo Di Scala, Jurgen Sota, Ida Orlando, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini

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Abstract

PURPOSE: To identify factors associated with sustained response to interleukin (IL)-1 inhibition among demographic, clinical and therapeutic data in patients with Behçet disease (BD).

METHODS: BD patients treated with anakinra or canakinumab were enrolled. Patients were divided into two groups according to the clinical response: group 1 included subjects showing a treatment duration of at least 52 weeks and no secondary inefficacy during the first follow-up year; the remaining patients were included in the group 2. Demographic, clinical and therapeutic data were analyzed to identify significant differences between groups.

RESULTS: Eighteen patients were included in group 1 and 18 patients in group 2. A better response to IL-1 inhibitors was significantly more common among patients with BD-related uveitis (p = 0.006) and patients with a longer disease duration (p = 0.03).

CONCLUSION: IL-1 blockade is effective in BD, especially in the subset of patients presenting eye involvement and in those with long-lasting disease.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalOcular Immunology and Inflammation
DOIs
Publication statusE-pub ahead of print - Aug 27 2018

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Fabiani, C., Vitale, A., Rigante, D., Emmi, G., Lopalco, G., Di Scala, G., Sota, J., Orlando, I., Franceschini, R., Frediani, B., Galeazzi, M., Iannone, F., Tosi, G. M., & Cantarini, L. (2018). The Presence of Uveitis Is Associated with a Sustained Response to the Interleukin (IL)-1 Inhibitors Anakinra and Canakinumab in Behçet's Disease. Ocular Immunology and Inflammation, 1-7. https://doi.org/10.1080/09273948.2018.1511810