The preservation of the ocular surface during chronic administration of hypotensive eye drops

P. Troiano, B. Cavallotti, A. Oldani, M. Iraci, L. Galli, M. Miglior

Research output: Contribution to journalArticlepeer-review


The aim of this clinical trial was to evaluate the effect of multidose therapy of primary open angle glaucoma (POAG) on tear fluid parameters. The effect of various preparations of preserved timolol 0.5% eye drops on lacrimal tear film stability (BUT), on basal lacrimal secretion (Jones test), on corneal epithelial cells (Rose bengal test) and on the symptomatology (foreign body sensation, photophobia, burning sensation) was evaluated. In this randomized controlled study, groups were formed according to the three different preparations of timolol used: 1) unpreserved, with hyaluronic acid as the vehicle, administered once daily, 2) unpreserved, with an aqueous solution as the vehicle, administered twice daily, and 3) preserved, with carbopol as the vehicle, administered twice daily. In both groups using unpreserved drags, a significant increase in BUT was observed. The Jones test showed no significant increase within 7 days of treatment. However, 30 days after treatment, a significant improvement was achieved in group i in comparison with the other groups. It was only in the groups treated with unpreserved solutions that a significant improvement of the epithelial cell status could be observed. We conclude that the side-effects of chronic administration of timolol on the ocular surface could be reduced by the use of unpreserved eye drops. Furthermore, the use of hyaluronic acid as the vehicle resulted in an increase in tear film stability, an improvement of the epithelial cell status and an increase in the basal lacrimal secretion.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
Issue numberSUPPL.
Publication statusPublished - 1997


  • Hypotensive eye drops
  • Lacrimal tear film stability
  • Ocular surface
  • Primary open angle glaucoma

ASJC Scopus subject areas

  • Ophthalmology


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