The prevalence of antibodies to human herpesvirus 8 and hepatitis B virus in patients in two hospitals in Tanzania

S. Meschi, M. Sañé Schepisi, E. Nicastri, N. Bevilacqua, C. Castilletti, M. R. Sciarrone, M. G. Paglia, R. Fumakule, J. Mohamed, A. Kitwa, S. Mangi, F. Molteni, A. Di Caro, F. Vairo, M. R. Capobianchi, G. Ippolito

Research output: Contribution to journalArticle

Abstract

The aim of this study was to determine the seroprevalence of human herpesvirus 8 (HHV-8) and the immunization status for hepatitis B virus (HBV) infection in febrile patients in two districts of the United Republic of Tanzania. Between February and March 2007, blood samples were collected in Pemba Island and Tosamaganga from 336 outpatients and sent to the Virology Laboratory in Rome (Italy) for testing. HHV-8DNA and HBV-DNA were amplified by two in-house molecular methods, anti-HHV-8 antibody titers were determined by an immunofluorescence assay (IFA), and anti-HCV, HBsAg, anti-HBs, and anti-HBc were evaluated by microplate enzyme immunoassay (MEIA). The seroprevalence of HHV-8 was 30.7% (96/313). In Pemba Island, the prevalence was lower than in Tosamaganga (14.4% vs. 46.3%). A higher prevalence of low titers of HHV-8 IgG (

Original languageEnglish
Pages (from-to)1569-1575
Number of pages7
JournalJournal of Medical Virology
Volume82
Issue number9
DOIs
Publication statusPublished - Sep 2010

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Keywords

  • Antibody titer
  • Hepatitis
  • Immunization
  • PCR
  • Seroprevalence

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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