The prevalence of apoE-ε4 in Alzheimer's disease is age dependent

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The ε4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. However, other yet unidentified factors might be involved. It has been suggested that the ε4 allele might be relatively less relevant in Alzheimer's disease with onset before age 60 and after age 80. The aim was to evaluate the association of the ε4 allele with Alzheimer's disease across a wide range of ages at onset. 156 patients with age at onset between 46 and 89 and 120 cognitively unimpared subjects aged 53 to 89 as controls were studied. Age at onset in the cases and age in the controls were stratified into six groups (60 and younger, 60 to 64, 65 to 69, 70 to 74, 75 to 79, and 80 and older). Multivariable sex adjusted probit regression analysis was used to model ε4 prevalences in cases and controls across age. The sex adjusted relation of ε4 with age in controls was slightly negative with prevalence of 0.16 in the youngest and 0.09 in the oldest age groups. The sex adjusted relation in cases with Alzheimer's disease had a bell shaped curve with prevalence of 0.23 in the youngest age group, rising to 0.54 and 0.51 in the age groups 65 to 69 and 70 to 74, and decreasing to 0.12 in the oldest age group. It is concluded that the relation of the ε4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume65
Issue number1
Publication statusPublished - 1998

Fingerprint

Apolipoproteins E
Alzheimer Disease
Age of Onset
Age Groups
Alleles
Apolipoprotein E4
Regression Analysis
Alzheimer disease type 4

Keywords

  • Age
  • Alzheimer's disease
  • Apolipoprotein E

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

The prevalence of apoE-ε4 in Alzheimer's disease is age dependent. / Frisoni, Giovanni B.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 65, No. 1, 1998, p. 103-106.

Research output: Contribution to journalArticle

@article{978809672be646b29d17c46c5e40a485,
title = "The prevalence of apoE-ε4 in Alzheimer's disease is age dependent",
abstract = "The ε4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. However, other yet unidentified factors might be involved. It has been suggested that the ε4 allele might be relatively less relevant in Alzheimer's disease with onset before age 60 and after age 80. The aim was to evaluate the association of the ε4 allele with Alzheimer's disease across a wide range of ages at onset. 156 patients with age at onset between 46 and 89 and 120 cognitively unimpared subjects aged 53 to 89 as controls were studied. Age at onset in the cases and age in the controls were stratified into six groups (60 and younger, 60 to 64, 65 to 69, 70 to 74, 75 to 79, and 80 and older). Multivariable sex adjusted probit regression analysis was used to model ε4 prevalences in cases and controls across age. The sex adjusted relation of ε4 with age in controls was slightly negative with prevalence of 0.16 in the youngest and 0.09 in the oldest age groups. The sex adjusted relation in cases with Alzheimer's disease had a bell shaped curve with prevalence of 0.23 in the youngest age group, rising to 0.54 and 0.51 in the age groups 65 to 69 and 70 to 74, and decreasing to 0.12 in the oldest age group. It is concluded that the relation of the ε4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages.",
keywords = "Age, Alzheimer's disease, Apolipoprotein E",
author = "Frisoni, {Giovanni B.}",
year = "1998",
language = "English",
volume = "65",
pages = "103--106",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - The prevalence of apoE-ε4 in Alzheimer's disease is age dependent

AU - Frisoni, Giovanni B.

PY - 1998

Y1 - 1998

N2 - The ε4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. However, other yet unidentified factors might be involved. It has been suggested that the ε4 allele might be relatively less relevant in Alzheimer's disease with onset before age 60 and after age 80. The aim was to evaluate the association of the ε4 allele with Alzheimer's disease across a wide range of ages at onset. 156 patients with age at onset between 46 and 89 and 120 cognitively unimpared subjects aged 53 to 89 as controls were studied. Age at onset in the cases and age in the controls were stratified into six groups (60 and younger, 60 to 64, 65 to 69, 70 to 74, 75 to 79, and 80 and older). Multivariable sex adjusted probit regression analysis was used to model ε4 prevalences in cases and controls across age. The sex adjusted relation of ε4 with age in controls was slightly negative with prevalence of 0.16 in the youngest and 0.09 in the oldest age groups. The sex adjusted relation in cases with Alzheimer's disease had a bell shaped curve with prevalence of 0.23 in the youngest age group, rising to 0.54 and 0.51 in the age groups 65 to 69 and 70 to 74, and decreasing to 0.12 in the oldest age group. It is concluded that the relation of the ε4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages.

AB - The ε4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. However, other yet unidentified factors might be involved. It has been suggested that the ε4 allele might be relatively less relevant in Alzheimer's disease with onset before age 60 and after age 80. The aim was to evaluate the association of the ε4 allele with Alzheimer's disease across a wide range of ages at onset. 156 patients with age at onset between 46 and 89 and 120 cognitively unimpared subjects aged 53 to 89 as controls were studied. Age at onset in the cases and age in the controls were stratified into six groups (60 and younger, 60 to 64, 65 to 69, 70 to 74, 75 to 79, and 80 and older). Multivariable sex adjusted probit regression analysis was used to model ε4 prevalences in cases and controls across age. The sex adjusted relation of ε4 with age in controls was slightly negative with prevalence of 0.16 in the youngest and 0.09 in the oldest age groups. The sex adjusted relation in cases with Alzheimer's disease had a bell shaped curve with prevalence of 0.23 in the youngest age group, rising to 0.54 and 0.51 in the age groups 65 to 69 and 70 to 74, and decreasing to 0.12 in the oldest age group. It is concluded that the relation of the ε4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages.

KW - Age

KW - Alzheimer's disease

KW - Apolipoprotein E

UR - http://www.scopus.com/inward/record.url?scp=0031597583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031597583&partnerID=8YFLogxK

M3 - Article

C2 - 9667569

AN - SCOPUS:0031597583

VL - 65

SP - 103

EP - 106

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 1

ER -