Abstract
BCL-2 protein plays a pivotal role in overriding programmed cell death (apoptosis), thus favouring a prolonged survival of normal and neoplastic cells. Expression of the bcl-2 gene has been documented in some human tumours (non-Hodgkin's lymphomas and prostatic adenocarcinomas), but findings in breast carcinomas have not been reported. We have used the monoclonal antibody 124 to investigate BCL-2 expression in 212 breast carcinomas, and to correlate it with the oestrogen (ER), progesterone (PR) and epidermal growth factor receptor (EGFR) status, and with other clinicopathological variables including tumour type, grade, stage, growth fraction (as evaluated by Ki-67 immunostaining), and p53 accumulation. Of the 212 carcinomas, 173 (81.6%) exhibited BCL-2 immunoreactivity in more than 25% of the neoplastic cells. BCL-2 immunoreactivity was strongly correlated with ER and PR expression (P
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Virchows Archiv |
| Volume | 424 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1994 |
Fingerprint
Keywords
- BCL-2 immunoreactivity
- Breast carcinoma
- Oestrogen receptors
- p53 accumulation
- Progesterone receptors
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status. / Doglioni, C.; Dei Tos, A.; Laurino, L.; Chiarelli, C.; Barbareschi, M.; Viale, G.
In: Virchows Archiv, Vol. 424, No. 1, 01.1994, p. 47-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status
AU - Doglioni, C.
AU - Dei Tos, A.
AU - Laurino, L.
AU - Chiarelli, C.
AU - Barbareschi, M.
AU - Viale, G.
PY - 1994/1
Y1 - 1994/1
N2 - BCL-2 protein plays a pivotal role in overriding programmed cell death (apoptosis), thus favouring a prolonged survival of normal and neoplastic cells. Expression of the bcl-2 gene has been documented in some human tumours (non-Hodgkin's lymphomas and prostatic adenocarcinomas), but findings in breast carcinomas have not been reported. We have used the monoclonal antibody 124 to investigate BCL-2 expression in 212 breast carcinomas, and to correlate it with the oestrogen (ER), progesterone (PR) and epidermal growth factor receptor (EGFR) status, and with other clinicopathological variables including tumour type, grade, stage, growth fraction (as evaluated by Ki-67 immunostaining), and p53 accumulation. Of the 212 carcinomas, 173 (81.6%) exhibited BCL-2 immunoreactivity in more than 25% of the neoplastic cells. BCL-2 immunoreactivity was strongly correlated with ER and PR expression (P
AB - BCL-2 protein plays a pivotal role in overriding programmed cell death (apoptosis), thus favouring a prolonged survival of normal and neoplastic cells. Expression of the bcl-2 gene has been documented in some human tumours (non-Hodgkin's lymphomas and prostatic adenocarcinomas), but findings in breast carcinomas have not been reported. We have used the monoclonal antibody 124 to investigate BCL-2 expression in 212 breast carcinomas, and to correlate it with the oestrogen (ER), progesterone (PR) and epidermal growth factor receptor (EGFR) status, and with other clinicopathological variables including tumour type, grade, stage, growth fraction (as evaluated by Ki-67 immunostaining), and p53 accumulation. Of the 212 carcinomas, 173 (81.6%) exhibited BCL-2 immunoreactivity in more than 25% of the neoplastic cells. BCL-2 immunoreactivity was strongly correlated with ER and PR expression (P
KW - BCL-2 immunoreactivity
KW - Breast carcinoma
KW - Oestrogen receptors
KW - p53 accumulation
KW - Progesterone receptors
UR - http://www.scopus.com/inward/record.url?scp=0028325283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028325283&partnerID=8YFLogxK
U2 - 10.1007/BF00197392
DO - 10.1007/BF00197392
M3 - Article
C2 - 7981903
AN - SCOPUS:0028325283
VL - 424
SP - 47
EP - 51
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 1
ER -