The prevalence of pain in multiple sclerosis: A multicenter cross-sectional study

Claudio Solaro, G. Brichetto, M. P. Amato, E. Cocco, B. Colombo, G. D'Aleo, C. Gasperini, A. Ghezzi, V. Martinelli, C. Milanese, F. Patti, M. Trojano, E. Verdun, G. L. Mancardi, P. Annunziata, S. Baldini, M. Zaffaroni, A. Bertolotto, S. Bonavita, P. BramantiE. Sessa, T. Fiorilla, A. Fuiani, M. Mazzoni, L. Mendozzi, E. Merelli, P. Sola, C. Pozzilli, E. Pucci, M. Pugliatti, C. Scandellari, M. R. Tola, A. Uccelli, A. Murialdo

Research output: Contribution to journalArticlepeer-review


In a multicenter cross-sectional study, the authors assessed pain in patients with multiple sclerosis (MS) using a symptom-oriented approach. Out of 2,077 questionnaires, we used 1,672 for data analysis. Pain and frequencies included trigeminal neuralgia 2%, Lhermitte's sign 9%, dysesthetic pain 18.1%, back pain 16.4%, and painful tonic spasms 11%. Comparison between different groups showed significant differences for age, Expanded Disability Status Scale, disease duration, and disease course, but not for sex. This study underlines the relevance of pain in the clinical history of MS.

Original languageEnglish
Pages (from-to)919-921
Number of pages3
Issue number5
Publication statusPublished - Sep 14 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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