La prevenzione dell'endocardite infettiva verso un sorprendente paradigma: Profilassi antibiotica limitata ai soggetti con rischio di endocardite a decorso sfavorevole

Translated title of the contribution: The prevention of infective endocarditis toward a surprising paradigm: antibiotic prophylaxis restricted to patients at risk of endocarditis with poor outcome

Giovanni La Canna, Iryna Arendar, Luca Fumagalli, Ottavio Alfieri

Research output: Contribution to journalArticle

Abstract

The rationale for antibiotic prophylaxis of infective endocarditis is based on reproducible evidence of experimental infection induced by bacteremia in previously damaged endothelium. However, in the absence of clinical evidence from randomized studies, the extensive practice of antibiotic prophylaxis has recently been limited to high-risk cardiac conditions to prevent poor outcome infective endocarditis. In addition, the new paradigm for prevention of endocarditis requires a comprehensive approach to extracardiac risk conditions (bacterial virulence, comorbidity, demographic variables), which may be responsible for an unfavorable clinical course, independent of preexistent cardiac disease. In particular, prevention of nosocomial infective endocarditis deserves special attention over and above the periprocedural antibiotic prophylaxis suggested by scientific guidelines, mainly focused on community-acquired endocarditis.

Translated title of the contributionThe prevention of infective endocarditis toward a surprising paradigm: antibiotic prophylaxis restricted to patients at risk of endocarditis with poor outcome
Original languageItalian
Pages (from-to)382-394
Number of pages13
JournalGiornale Italiano di Cardiologia
Volume10
Issue number6
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The prevention of infective endocarditis toward a surprising paradigm: antibiotic prophylaxis restricted to patients at risk of endocarditis with poor outcome'. Together they form a unique fingerprint.

  • Cite this