The problem of identification of prognostic factors for persistent trophoblastic disease

Fabio Parazzini, Giorgia Mangili, Carlo Belloni, Carlo La Vecchia, Paola Liati, Roberta Marabini

Research output: Contribution to journalArticlepeer-review

Abstract

The role of anamnestic and clinical factors in defining the high group at risk of developing persistent trophoblastic disease (PTD) has been analyzed in 301 cases of hydatidiform mole. Patients age 40 or more years with AB blood, and a previous history of molar pregnancy had an elevated risk of developing PTD. The presence of various risk factors increased the frequency of PTD. However, with discriminant analysis, correct classification of outcome was obtained for only 69% of cases. Despite the magnitude of risk of PTD for women with three or more risk factors, the clinical relevance of prognostic variables in the prediction of outcome was limited by the low proportion of women classified in the low- and high-risk groups, making the identification at diagnosis of the women who could benefit of prophylactic chemotherapy extremely difficult and hence of little clinical importance.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalGynecologic Oncology
Volume30
Issue number1
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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