The prognosis of idiopathic optic neuritis

A. Ghezzi, V. Martinelli, M. Rodegher, M. Zaffaroni, G. Comi

Research output: Contribution to journalArticle

Abstract

We evaluated the risk of developing clinically definite multiple sclerosis (CDMS) after acute isolated optic neuritis in 102 patients in a follow-up study (duration 6.5 ± 2.0 years). The probability of CDMS was 13% after 2 years, 30% after 4 years, 38% after 6 years, and 49% after 8 and 10 years. CDMS occurred in 42 (59%) of 71 patients with brain lesions detected with magnetic resonance imaging (MRI). No patient with normal MRI exam developed the disease. Patients with 3 or more MRI-detected lesions presented a shorter first interattack interval and a higher relapse rate compared to subjects with only 1 or 2 lesions. The predictive value of CSF examination and of evoked potentials was poor.

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number8
Publication statusPublished - 2000

Fingerprint

Optic Neuritis
Multiple Sclerosis
Magnetic Resonance Imaging
Evoked Potentials
Recurrence
Brain

Keywords

  • CSF examination
  • Evoked potentials
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Oligoclonal bands
  • Optic neuritis

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

The prognosis of idiopathic optic neuritis. / Ghezzi, A.; Martinelli, V.; Rodegher, M.; Zaffaroni, M.; Comi, G.

In: Neurological Sciences, Vol. 21, No. 8, 2000.

Research output: Contribution to journalArticle

Ghezzi, A, Martinelli, V, Rodegher, M, Zaffaroni, M & Comi, G 2000, 'The prognosis of idiopathic optic neuritis', Neurological Sciences, vol. 21, no. 8.
Ghezzi, A. ; Martinelli, V. ; Rodegher, M. ; Zaffaroni, M. ; Comi, G. / The prognosis of idiopathic optic neuritis. In: Neurological Sciences. 2000 ; Vol. 21, No. 8.
@article{d2bd73f2a08244f88adad43bccdbd39d,
title = "The prognosis of idiopathic optic neuritis",
abstract = "We evaluated the risk of developing clinically definite multiple sclerosis (CDMS) after acute isolated optic neuritis in 102 patients in a follow-up study (duration 6.5 ± 2.0 years). The probability of CDMS was 13{\%} after 2 years, 30{\%} after 4 years, 38{\%} after 6 years, and 49{\%} after 8 and 10 years. CDMS occurred in 42 (59{\%}) of 71 patients with brain lesions detected with magnetic resonance imaging (MRI). No patient with normal MRI exam developed the disease. Patients with 3 or more MRI-detected lesions presented a shorter first interattack interval and a higher relapse rate compared to subjects with only 1 or 2 lesions. The predictive value of CSF examination and of evoked potentials was poor.",
keywords = "CSF examination, Evoked potentials, Magnetic resonance imaging, Multiple sclerosis, Oligoclonal bands, Optic neuritis",
author = "A. Ghezzi and V. Martinelli and M. Rodegher and M. Zaffaroni and G. Comi",
year = "2000",
language = "English",
volume = "21",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "8",

}

TY - JOUR

T1 - The prognosis of idiopathic optic neuritis

AU - Ghezzi, A.

AU - Martinelli, V.

AU - Rodegher, M.

AU - Zaffaroni, M.

AU - Comi, G.

PY - 2000

Y1 - 2000

N2 - We evaluated the risk of developing clinically definite multiple sclerosis (CDMS) after acute isolated optic neuritis in 102 patients in a follow-up study (duration 6.5 ± 2.0 years). The probability of CDMS was 13% after 2 years, 30% after 4 years, 38% after 6 years, and 49% after 8 and 10 years. CDMS occurred in 42 (59%) of 71 patients with brain lesions detected with magnetic resonance imaging (MRI). No patient with normal MRI exam developed the disease. Patients with 3 or more MRI-detected lesions presented a shorter first interattack interval and a higher relapse rate compared to subjects with only 1 or 2 lesions. The predictive value of CSF examination and of evoked potentials was poor.

AB - We evaluated the risk of developing clinically definite multiple sclerosis (CDMS) after acute isolated optic neuritis in 102 patients in a follow-up study (duration 6.5 ± 2.0 years). The probability of CDMS was 13% after 2 years, 30% after 4 years, 38% after 6 years, and 49% after 8 and 10 years. CDMS occurred in 42 (59%) of 71 patients with brain lesions detected with magnetic resonance imaging (MRI). No patient with normal MRI exam developed the disease. Patients with 3 or more MRI-detected lesions presented a shorter first interattack interval and a higher relapse rate compared to subjects with only 1 or 2 lesions. The predictive value of CSF examination and of evoked potentials was poor.

KW - CSF examination

KW - Evoked potentials

KW - Magnetic resonance imaging

KW - Multiple sclerosis

KW - Oligoclonal bands

KW - Optic neuritis

UR - http://www.scopus.com/inward/record.url?scp=0034566049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034566049&partnerID=8YFLogxK

M3 - Article

C2 - 11205365

AN - SCOPUS:0034566049

VL - 21

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 8

ER -