The prognosis of idiopathic optic neuritis

A. Ghezzi, V. Martinelli, M. Rodegher, M. Zaffaroni, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the risk of developing clinically definite multiple sclerosis (CDMS) after acute isolated optic neuritis in 102 patients in a follow-up study (duration 6.5 ± 2.0 years). The probability of CDMS was 13% after 2 years, 30% after 4 years, 38% after 6 years, and 49% after 8 and 10 years. CDMS occurred in 42 (59%) of 71 patients with brain lesions detected with magnetic resonance imaging (MRI). No patient with normal MRI exam developed the disease. Patients with 3 or more MRI-detected lesions presented a shorter first interattack interval and a higher relapse rate compared to subjects with only 1 or 2 lesions. The predictive value of CSF examination and of evoked potentials was poor.

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number8
Publication statusPublished - 2000

Keywords

  • CSF examination
  • Evoked potentials
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Oligoclonal bands
  • Optic neuritis

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

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