Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario.

Translated title of the contribution: The prognostic factors for the radiation treatment of the cerebral metastases from breast carcinoma

M. Busetto, R. Polico, M. Antonello, G. Conte, M. Masato, C. Ravenna, A. Bruscagnin

Research output: Contribution to journalArticle

Abstract

Complex mechanisms of various nature, not only physical, can influence the patterns of metastases. We compared the patients with recurrences to the brain as the only metastatic site from breast cancer with the patients relapsing in the brain and other organs. All cases were staged and treated following professional protocols. When brain metastases were diagnosed, the patients were accurately restaged before being submitted to radiation therapy; the whole brain was irradiated with various total doses and the same fractionation. The patients underwent clinical examination before and after irradiation. Survival analysis was carried out using the product-limit method considering the following periods: total survival, relapse-free survival, elapsed time till the appearance of brain metastases, and survival after radiation therapy. The cases were grouped and compared using Mantel-Cox and Breslow methods according to the following prognostic factors: brain as the first site of recurrence, pausal state, total radiation dose, stage (TNM), T and N. No significant difference in survival was observed between the cases with brain as the first metastasized organ and the others. The patients were grouped according to the extant prognostic factors: longer total and postirradiation survival rates were observed in patients in premenopausal state (Breslow: p = 0.025 and 0.005) and in the cases treated with total radiation doses greater than 40 Gy (Breslow: p = 0.023 and 0.005). T levels seemed to significantly affect all the examined periods--which influences the stage effect. Conversely, N levels seemed to be of no significant value. The menopausal factor may reflect the effects of age, from which it cannot be separated. These results can be useful for treatment planning.

Original languageItalian
Pages (from-to)652-657
Number of pages6
JournalRadiologia Medica
Volume82
Issue number5
Publication statusPublished - Nov 1991

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Radiation
Breast Neoplasms
Neoplasm Metastasis
Brain
Survival
Recurrence
Therapeutics
Radiotherapy
Dose Fractionation
Kaplan-Meier Estimate
Survival Analysis
Survival Rate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Busetto, M., Polico, R., Antonello, M., Conte, G., Masato, M., Ravenna, C., & Bruscagnin, A. (1991). Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario. Radiologia Medica, 82(5), 652-657.

Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario. / Busetto, M.; Polico, R.; Antonello, M.; Conte, G.; Masato, M.; Ravenna, C.; Bruscagnin, A.

In: Radiologia Medica, Vol. 82, No. 5, 11.1991, p. 652-657.

Research output: Contribution to journalArticle

Busetto, M, Polico, R, Antonello, M, Conte, G, Masato, M, Ravenna, C & Bruscagnin, A 1991, 'Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario.', Radiologia Medica, vol. 82, no. 5, pp. 652-657.
Busetto M, Polico R, Antonello M, Conte G, Masato M, Ravenna C et al. Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario. Radiologia Medica. 1991 Nov;82(5):652-657.
Busetto, M. ; Polico, R. ; Antonello, M. ; Conte, G. ; Masato, M. ; Ravenna, C. ; Bruscagnin, A. / Fattori prognostici per il trattamento radiante delle metastasi cerebrali da carcinoma mammario. In: Radiologia Medica. 1991 ; Vol. 82, No. 5. pp. 652-657.
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