TY - JOUR
T1 - The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS
AU - D'Andrea, Antonello
AU - Mele, Donato
AU - Nistri, Stefano
AU - Riegler, Lucia
AU - Galderisi, Maurizio
AU - Agricola, Eustachio
AU - Losi, Maria Angela
AU - Ballo, Piercarlo
AU - Mondillo, Sergio
AU - Badano, Luigi P.
PY - 2013/2
Y1 - 2013/2
N2 - AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration
AB - AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration
KW - Cardiac resynchronization therapy
KW - Dilated cardiomyopathy
KW - Dynamic dyssynchrony
KW - Exercise echocardiography
KW - Functional mitral regurgitation
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84872466742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872466742&partnerID=8YFLogxK
U2 - 10.1093/ehjci/jes154
DO - 10.1093/ehjci/jes154
M3 - Article
C2 - 22872513
AN - SCOPUS:84872466742
VL - 14
SP - 183
EP - 189
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 2
ER -