The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS

Antonello D'Andrea; Donato Mele; Stefano Nistri; Lucia Riegler; Maurizio Galderisi; Eustachio Agricola; Maria Angela Losi; Piercarlo Ballo; Sergio Mondillo; Luigi P. Badano

doi:10.1093/ehjci/jes154

The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS

Antonello D'Andrea, Donato Mele, Stefano Nistri, Lucia Riegler, Maurizio Galderisi, Eustachio Agricola, Maria Angela Losi, Piercarlo Ballo, Sergio Mondillo, Luigi P. Badano

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration

Original language	English
Pages (from-to)	183-189
Number of pages	7
Journal	European Heart Journal Cardiovascular Imaging
Volume	14
Issue number	2
DOIs	https://doi.org/10.1093/ehjci/jes154
Publication status	Published - Feb 2013

Keywords

Cardiac resynchronization therapy
Dilated cardiomyopathy
Dynamic dyssynchrony
Exercise echocardiography
Functional mitral regurgitation
Prognosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1093/ehjci/jes154

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The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS. / D'Andrea, Antonello; Mele, Donato; Nistri, Stefano; Riegler, Lucia; Galderisi, Maurizio; Agricola, Eustachio; Losi, Maria Angela; Ballo, Piercarlo; Mondillo, Sergio; Badano, Luigi P.

In: European Heart Journal Cardiovascular Imaging, Vol. 14, No. 2, 02.2013, p. 183-189.

Research output: Contribution to journal › Article › peer-review

D'Andrea, Antonello ; Mele, Donato ; Nistri, Stefano ; Riegler, Lucia ; Galderisi, Maurizio ; Agricola, Eustachio ; Losi, Maria Angela ; Ballo, Piercarlo ; Mondillo, Sergio ; Badano, Luigi P. / The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS. In: European Heart Journal Cardiovascular Imaging. 2013 ; Vol. 14, No. 2. pp. 183-189.

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abstract = "AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration ",

keywords = "Cardiac resynchronization therapy, Dilated cardiomyopathy, Dynamic dyssynchrony, Exercise echocardiography, Functional mitral regurgitation, Prognosis",

author = "Antonello D'Andrea and Donato Mele and Stefano Nistri and Lucia Riegler and Maurizio Galderisi and Eustachio Agricola and Losi, {Maria Angela} and Piercarlo Ballo and Sergio Mondillo and Badano, {Luigi P.}",

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AU - D'Andrea, Antonello

AU - Mele, Donato

AU - Nistri, Stefano

AU - Riegler, Lucia

AU - Galderisi, Maurizio

AU - Agricola, Eustachio

AU - Losi, Maria Angela

AU - Ballo, Piercarlo

AU - Mondillo, Sergio

AU - Badano, Luigi P.

PY - 2013/2

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AB - AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration

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KW - Dilated cardiomyopathy

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KW - Exercise echocardiography

KW - Functional mitral regurgitation

KW - Prognosis

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