The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS

Antonello D'Andrea, Donato Mele, Stefano Nistri, Lucia Riegler, Maurizio Galderisi, Eustachio Agricola, Maria Angela Losi, Piercarlo Ballo, Sergio Mondillo, Luigi P. Badano

Research output: Contribution to journalArticlepeer-review

Abstract

AimsAsynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation.Methods and resultsA prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and 'narrow' QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II-III, idiopathic DCM, ejection fraction ≤35%, and QRS duration

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalEuropean Heart Journal Cardiovascular Imaging
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cardiac resynchronization therapy
  • Dilated cardiomyopathy
  • Dynamic dyssynchrony
  • Exercise echocardiography
  • Functional mitral regurgitation
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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