The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL)

Elena Maiolo, Eleonora Alma, Cecilia Napodano, Francesca Gulli, Silvia Bellesi, Annarosa Cuccaro, Krizia Pocino, Francesco D'Alo', Marco Iachini, Maurizio Martini, Luigi Maria Larocca, Valerio De Stefano, Umberto Basile, Stefan Hohaus

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Abstract

We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of κ-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and κ-FLC >50 mg/L had a significant inferior event-free survival (p = .004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p = .008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalLeukemia and Lymphoma
DOIs
Publication statusE-pub ahead of print - Dec 31 2019

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