The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients

Matteo Lambertini, Ana Catarina Pinto, Lieveke Ameye, Lynn Jongen, Lucia Del Mastro, Fabio Puglisi, Francesca Poggio, Marta Bonotto, Giuseppe Floris, Kathleen van Asten, Hans Wildiers, Patrick Neven, Evandro de Azambuja, Marianne Paesmans, Hatem A. Azim

Research output: Contribution to journalArticle

Abstract

Background:Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients.Methods:This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed.Results:The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P=0.37) in young cohort, but overestimated 10-year DFS by 7.7% (P=0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% (P<0.001) and 3.2% (P=0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5%; P<0.001) and older (4.0%; P<0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy.Conclusions:In young breast cancer patients, AOL is a reliable tool in predicting OS at 10 years but not DFS, whereas the performance of NPI is sub-optimal.British Journal of Cancer advance online publication, 1 November 2016; doi:10.1038/bjc.2016.359 www.bjcancer.com.

Original languageEnglish
JournalBritish Journal of Cancer
DOIs
Publication statusAccepted/In press - Nov 1 2016

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Breast Neoplasms
Disease-Free Survival
Survival
Calibration
Publications
Cohort Studies
Retrospective Studies
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients. / Lambertini, Matteo; Pinto, Ana Catarina; Ameye, Lieveke; Jongen, Lynn; Del Mastro, Lucia; Puglisi, Fabio; Poggio, Francesca; Bonotto, Marta; Floris, Giuseppe; van Asten, Kathleen; Wildiers, Hans; Neven, Patrick; de Azambuja, Evandro; Paesmans, Marianne; Azim, Hatem A.

In: British Journal of Cancer, 01.11.2016.

Research output: Contribution to journalArticle

Lambertini, M, Pinto, AC, Ameye, L, Jongen, L, Del Mastro, L, Puglisi, F, Poggio, F, Bonotto, M, Floris, G, van Asten, K, Wildiers, H, Neven, P, de Azambuja, E, Paesmans, M & Azim, HA 2016, 'The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients', British Journal of Cancer. https://doi.org/10.1038/bjc.2016.359
Lambertini, Matteo ; Pinto, Ana Catarina ; Ameye, Lieveke ; Jongen, Lynn ; Del Mastro, Lucia ; Puglisi, Fabio ; Poggio, Francesca ; Bonotto, Marta ; Floris, Giuseppe ; van Asten, Kathleen ; Wildiers, Hans ; Neven, Patrick ; de Azambuja, Evandro ; Paesmans, Marianne ; Azim, Hatem A. / The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients. In: British Journal of Cancer. 2016.
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abstract = "Background:Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients.Methods:This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed.Results:The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7{\%}; P=0.37) in young cohort, but overestimated 10-year DFS by 7.7{\%} (P=0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2{\%} (P<0.001) and 3.2{\%} (P=0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5{\%}; P<0.001) and older (4.0{\%}; P<0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy.Conclusions:In young breast cancer patients, AOL is a reliable tool in predicting OS at 10 years but not DFS, whereas the performance of NPI is sub-optimal.British Journal of Cancer advance online publication, 1 November 2016; doi:10.1038/bjc.2016.359 www.bjcancer.com.",
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T1 - The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients

AU - Lambertini, Matteo

AU - Pinto, Ana Catarina

AU - Ameye, Lieveke

AU - Jongen, Lynn

AU - Del Mastro, Lucia

AU - Puglisi, Fabio

AU - Poggio, Francesca

AU - Bonotto, Marta

AU - Floris, Giuseppe

AU - van Asten, Kathleen

AU - Wildiers, Hans

AU - Neven, Patrick

AU - de Azambuja, Evandro

AU - Paesmans, Marianne

AU - Azim, Hatem A.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background:Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients.Methods:This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed.Results:The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P=0.37) in young cohort, but overestimated 10-year DFS by 7.7% (P=0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% (P<0.001) and 3.2% (P=0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5%; P<0.001) and older (4.0%; P<0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy.Conclusions:In young breast cancer patients, AOL is a reliable tool in predicting OS at 10 years but not DFS, whereas the performance of NPI is sub-optimal.British Journal of Cancer advance online publication, 1 November 2016; doi:10.1038/bjc.2016.359 www.bjcancer.com.

AB - Background:Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients.Methods:This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed.Results:The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P=0.37) in young cohort, but overestimated 10-year DFS by 7.7% (P=0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% (P<0.001) and 3.2% (P=0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5%; P<0.001) and older (4.0%; P<0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy.Conclusions:In young breast cancer patients, AOL is a reliable tool in predicting OS at 10 years but not DFS, whereas the performance of NPI is sub-optimal.British Journal of Cancer advance online publication, 1 November 2016; doi:10.1038/bjc.2016.359 www.bjcancer.com.

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