The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration

A. Mattesini, C. Lazzeri, M. Chiostri, C. Cordopatri, C. Sorini Dini, G. F. Gensini, S. Valente

Research output: Contribution to journalArticle

Abstract

Aim. The present investigation was aimed at assessing the prognostic impact of renal dysfunction rate in STEMI patients submitted to thrombectomy (TP). Methods. Out of 1268 consecutive ST elevation myocardial infarction (STEMI) patients treated with pPCI from January 1rst 2004 to December 31th 2012 in our hospital 671 patients (52.9%) underwent adjunctive thrombus aspiration and constituted the study population. Patients were divided into three groups according to EGFR: group 1 included patients with EGFR>60 mL/min/m2, group 2 EGFR>30 mL/min/m2 and <60 mL/min/m2, group 3 EGFR<30 mL/min/m2. The rate of utilization of thrombectomy, the rate of pPCI failure and the incidence of major bleeding were assessed in each subgroup. Patients in group 3 and group 2 were less likely to be submitted to TP, while more than 50% of patients with normal EGFR underwent TP (overall P=0.019). The rate of pPCI failure was significantly higher in group 2 and 3 when compared to group 1 (P=0.002). Worsening renal failure was associated with a higher mortality rate both at ICCU and at 1 year follow- up (P<0.001 and P<0.001, respectively). A higher incidence of major bleedings was reported in group 2 and group 3, despite the lower administration of glycoprotein IIb/IIIa inhibitors (P<0.001). Moderate and severe renal impairment was associated with a higher mortality rate both at ICCU and at 1 year follow-up (P<0.001 and P<0.001, respectively). Conclusion. Thrombus aspiration is less like to be performed among patients with impaired renal function. Despite thrombus aspiration patients with reduced EGFR showed a higher incidence of pPCI failure.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalMinerva Cardioangiologica
Volume63
Issue number5
Publication statusPublished - Oct 1 2015

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Thrombosis
Kidney
Thrombectomy
Incidence
Hemorrhage
ST Elevation Myocardial Infarction
Platelet Glycoprotein GPIIb-IIIa Complex
Mortality
Renal Insufficiency
Population

Keywords

  • Kidney disease
  • Percutaneous coronary intervention
  • Thrombectomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mattesini, A., Lazzeri, C., Chiostri, M., Cordopatri, C., Sorini Dini, C., Gensini, G. F., & Valente, S. (2015). The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration. Minerva Cardioangiologica, 63(5), 381-388.

The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration. / Mattesini, A.; Lazzeri, C.; Chiostri, M.; Cordopatri, C.; Sorini Dini, C.; Gensini, G. F.; Valente, S.

In: Minerva Cardioangiologica, Vol. 63, No. 5, 01.10.2015, p. 381-388.

Research output: Contribution to journalArticle

Mattesini, A, Lazzeri, C, Chiostri, M, Cordopatri, C, Sorini Dini, C, Gensini, GF & Valente, S 2015, 'The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration', Minerva Cardioangiologica, vol. 63, no. 5, pp. 381-388.
Mattesini A, Lazzeri C, Chiostri M, Cordopatri C, Sorini Dini C, Gensini GF et al. The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration. Minerva Cardioangiologica. 2015 Oct 1;63(5):381-388.
Mattesini, A. ; Lazzeri, C. ; Chiostri, M. ; Cordopatri, C. ; Sorini Dini, C. ; Gensini, G. F. ; Valente, S. / The prognostic role of renal dysfunction in STEMI patients submitted to primary PCI with adjunctive thrombus aspiration. In: Minerva Cardioangiologica. 2015 ; Vol. 63, No. 5. pp. 381-388.
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abstract = "Aim. The present investigation was aimed at assessing the prognostic impact of renal dysfunction rate in STEMI patients submitted to thrombectomy (TP). Methods. Out of 1268 consecutive ST elevation myocardial infarction (STEMI) patients treated with pPCI from January 1rst 2004 to December 31th 2012 in our hospital 671 patients (52.9{\%}) underwent adjunctive thrombus aspiration and constituted the study population. Patients were divided into three groups according to EGFR: group 1 included patients with EGFR>60 mL/min/m2, group 2 EGFR>30 mL/min/m2 and <60 mL/min/m2, group 3 EGFR<30 mL/min/m2. The rate of utilization of thrombectomy, the rate of pPCI failure and the incidence of major bleeding were assessed in each subgroup. Patients in group 3 and group 2 were less likely to be submitted to TP, while more than 50{\%} of patients with normal EGFR underwent TP (overall P=0.019). The rate of pPCI failure was significantly higher in group 2 and 3 when compared to group 1 (P=0.002). Worsening renal failure was associated with a higher mortality rate both at ICCU and at 1 year follow- up (P<0.001 and P<0.001, respectively). A higher incidence of major bleedings was reported in group 2 and group 3, despite the lower administration of glycoprotein IIb/IIIa inhibitors (P<0.001). Moderate and severe renal impairment was associated with a higher mortality rate both at ICCU and at 1 year follow-up (P<0.001 and P<0.001, respectively). Conclusion. Thrombus aspiration is less like to be performed among patients with impaired renal function. Despite thrombus aspiration patients with reduced EGFR showed a higher incidence of pPCI failure.",
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AU - Mattesini, A.

AU - Lazzeri, C.

AU - Chiostri, M.

AU - Cordopatri, C.

AU - Sorini Dini, C.

AU - Gensini, G. F.

AU - Valente, S.

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N2 - Aim. The present investigation was aimed at assessing the prognostic impact of renal dysfunction rate in STEMI patients submitted to thrombectomy (TP). Methods. Out of 1268 consecutive ST elevation myocardial infarction (STEMI) patients treated with pPCI from January 1rst 2004 to December 31th 2012 in our hospital 671 patients (52.9%) underwent adjunctive thrombus aspiration and constituted the study population. Patients were divided into three groups according to EGFR: group 1 included patients with EGFR>60 mL/min/m2, group 2 EGFR>30 mL/min/m2 and <60 mL/min/m2, group 3 EGFR<30 mL/min/m2. The rate of utilization of thrombectomy, the rate of pPCI failure and the incidence of major bleeding were assessed in each subgroup. Patients in group 3 and group 2 were less likely to be submitted to TP, while more than 50% of patients with normal EGFR underwent TP (overall P=0.019). The rate of pPCI failure was significantly higher in group 2 and 3 when compared to group 1 (P=0.002). Worsening renal failure was associated with a higher mortality rate both at ICCU and at 1 year follow- up (P<0.001 and P<0.001, respectively). A higher incidence of major bleedings was reported in group 2 and group 3, despite the lower administration of glycoprotein IIb/IIIa inhibitors (P<0.001). Moderate and severe renal impairment was associated with a higher mortality rate both at ICCU and at 1 year follow-up (P<0.001 and P<0.001, respectively). Conclusion. Thrombus aspiration is less like to be performed among patients with impaired renal function. Despite thrombus aspiration patients with reduced EGFR showed a higher incidence of pPCI failure.

AB - Aim. The present investigation was aimed at assessing the prognostic impact of renal dysfunction rate in STEMI patients submitted to thrombectomy (TP). Methods. Out of 1268 consecutive ST elevation myocardial infarction (STEMI) patients treated with pPCI from January 1rst 2004 to December 31th 2012 in our hospital 671 patients (52.9%) underwent adjunctive thrombus aspiration and constituted the study population. Patients were divided into three groups according to EGFR: group 1 included patients with EGFR>60 mL/min/m2, group 2 EGFR>30 mL/min/m2 and <60 mL/min/m2, group 3 EGFR<30 mL/min/m2. The rate of utilization of thrombectomy, the rate of pPCI failure and the incidence of major bleeding were assessed in each subgroup. Patients in group 3 and group 2 were less likely to be submitted to TP, while more than 50% of patients with normal EGFR underwent TP (overall P=0.019). The rate of pPCI failure was significantly higher in group 2 and 3 when compared to group 1 (P=0.002). Worsening renal failure was associated with a higher mortality rate both at ICCU and at 1 year follow- up (P<0.001 and P<0.001, respectively). A higher incidence of major bleedings was reported in group 2 and group 3, despite the lower administration of glycoprotein IIb/IIIa inhibitors (P<0.001). Moderate and severe renal impairment was associated with a higher mortality rate both at ICCU and at 1 year follow-up (P<0.001 and P<0.001, respectively). Conclusion. Thrombus aspiration is less like to be performed among patients with impaired renal function. Despite thrombus aspiration patients with reduced EGFR showed a higher incidence of pPCI failure.

KW - Kidney disease

KW - Percutaneous coronary intervention

KW - Thrombectomy

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