The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple myeloma

A comparative study with Tc-99m sestamibi

Massimo Castellani, Marco Carletto, Luca Baldini, Rossella Calori, Virgilio Longari, Davide Soligo, Luca Dellavedova, Paolo Gerundini

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: We assessed the prognostic value of F-18 fluorodeoxyglucose (FDG) uptake in the bone marrow of patients with multiple myeloma (MM) in comparison with Tc-99m methoxy-isobutyl-isonitrile (MIBI). Methods: The extent and intensity of FDG and MIBI uptake in the bone marrow of 18 patients with a recent diagnosis of MM were assessed by visual score and by calculating the mean SUV (mSUV) for FDG and the femora/thigh ratio (TG/BKG, [Target/Background ratio]) for MIBI images. These parameters were correlated with clinical indexes of disease using hemoglobin and beta-2-microglobulin levels and plasma cell infiltrate (PCI) percentage. The mean values of the visual score, mSUV, and TG/BKG levels were compared in patients deceased after a relatively short follow-up (n = 9; group A) and in patients with a longer survival or were alive at the end of the study (n = 9; group B). Results: Significant correlations of mSUV and TG/BKG values with PCI percentages and beta-2-microglobulin were found (P <0.05). The extent of FDG and MIBI bone marrow uptake was greater in patients of group A (P <0.01). Higher values of mSUV (P <0.01) and TG/BKG (P <0.05) were also observed in patients of group A. These results were consistent with the differences (not statistically significant) in hemoglobin, albumin, beta-2-microglobulin levels, and PCI percentages observed in the 2 groups. Conclusion: Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalClinical Nuclear Medicine
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Fluorodeoxyglucose F18
Multiple Myeloma
Bone Marrow
beta 2-Microglobulin
Plasma Cells
Hemoglobins
Thigh
Femur
Albumins
Survival

Keywords

  • FDG-PET
  • MIBI scintigraphy
  • Multiple myeloma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple myeloma : A comparative study with Tc-99m sestamibi. / Castellani, Massimo; Carletto, Marco; Baldini, Luca; Calori, Rossella; Longari, Virgilio; Soligo, Davide; Dellavedova, Luca; Gerundini, Paolo.

In: Clinical Nuclear Medicine, Vol. 35, No. 1, 01.2010, p. 1-5.

Research output: Contribution to journalArticle

@article{6ae2f5d93d14412691c44a2e1d36d5f5,
title = "The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple myeloma: A comparative study with Tc-99m sestamibi",
abstract = "Purpose: We assessed the prognostic value of F-18 fluorodeoxyglucose (FDG) uptake in the bone marrow of patients with multiple myeloma (MM) in comparison with Tc-99m methoxy-isobutyl-isonitrile (MIBI). Methods: The extent and intensity of FDG and MIBI uptake in the bone marrow of 18 patients with a recent diagnosis of MM were assessed by visual score and by calculating the mean SUV (mSUV) for FDG and the femora/thigh ratio (TG/BKG, [Target/Background ratio]) for MIBI images. These parameters were correlated with clinical indexes of disease using hemoglobin and beta-2-microglobulin levels and plasma cell infiltrate (PCI) percentage. The mean values of the visual score, mSUV, and TG/BKG levels were compared in patients deceased after a relatively short follow-up (n = 9; group A) and in patients with a longer survival or were alive at the end of the study (n = 9; group B). Results: Significant correlations of mSUV and TG/BKG values with PCI percentages and beta-2-microglobulin were found (P <0.05). The extent of FDG and MIBI bone marrow uptake was greater in patients of group A (P <0.01). Higher values of mSUV (P <0.01) and TG/BKG (P <0.05) were also observed in patients of group A. These results were consistent with the differences (not statistically significant) in hemoglobin, albumin, beta-2-microglobulin levels, and PCI percentages observed in the 2 groups. Conclusion: Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM.",
keywords = "FDG-PET, MIBI scintigraphy, Multiple myeloma",
author = "Massimo Castellani and Marco Carletto and Luca Baldini and Rossella Calori and Virgilio Longari and Davide Soligo and Luca Dellavedova and Paolo Gerundini",
year = "2010",
month = "1",
doi = "10.1097/RLU.0b013e3181c3619c",
language = "English",
volume = "35",
pages = "1--5",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple myeloma

T2 - A comparative study with Tc-99m sestamibi

AU - Castellani, Massimo

AU - Carletto, Marco

AU - Baldini, Luca

AU - Calori, Rossella

AU - Longari, Virgilio

AU - Soligo, Davide

AU - Dellavedova, Luca

AU - Gerundini, Paolo

PY - 2010/1

Y1 - 2010/1

N2 - Purpose: We assessed the prognostic value of F-18 fluorodeoxyglucose (FDG) uptake in the bone marrow of patients with multiple myeloma (MM) in comparison with Tc-99m methoxy-isobutyl-isonitrile (MIBI). Methods: The extent and intensity of FDG and MIBI uptake in the bone marrow of 18 patients with a recent diagnosis of MM were assessed by visual score and by calculating the mean SUV (mSUV) for FDG and the femora/thigh ratio (TG/BKG, [Target/Background ratio]) for MIBI images. These parameters were correlated with clinical indexes of disease using hemoglobin and beta-2-microglobulin levels and plasma cell infiltrate (PCI) percentage. The mean values of the visual score, mSUV, and TG/BKG levels were compared in patients deceased after a relatively short follow-up (n = 9; group A) and in patients with a longer survival or were alive at the end of the study (n = 9; group B). Results: Significant correlations of mSUV and TG/BKG values with PCI percentages and beta-2-microglobulin were found (P <0.05). The extent of FDG and MIBI bone marrow uptake was greater in patients of group A (P <0.01). Higher values of mSUV (P <0.01) and TG/BKG (P <0.05) were also observed in patients of group A. These results were consistent with the differences (not statistically significant) in hemoglobin, albumin, beta-2-microglobulin levels, and PCI percentages observed in the 2 groups. Conclusion: Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM.

AB - Purpose: We assessed the prognostic value of F-18 fluorodeoxyglucose (FDG) uptake in the bone marrow of patients with multiple myeloma (MM) in comparison with Tc-99m methoxy-isobutyl-isonitrile (MIBI). Methods: The extent and intensity of FDG and MIBI uptake in the bone marrow of 18 patients with a recent diagnosis of MM were assessed by visual score and by calculating the mean SUV (mSUV) for FDG and the femora/thigh ratio (TG/BKG, [Target/Background ratio]) for MIBI images. These parameters were correlated with clinical indexes of disease using hemoglobin and beta-2-microglobulin levels and plasma cell infiltrate (PCI) percentage. The mean values of the visual score, mSUV, and TG/BKG levels were compared in patients deceased after a relatively short follow-up (n = 9; group A) and in patients with a longer survival or were alive at the end of the study (n = 9; group B). Results: Significant correlations of mSUV and TG/BKG values with PCI percentages and beta-2-microglobulin were found (P <0.05). The extent of FDG and MIBI bone marrow uptake was greater in patients of group A (P <0.01). Higher values of mSUV (P <0.01) and TG/BKG (P <0.05) were also observed in patients of group A. These results were consistent with the differences (not statistically significant) in hemoglobin, albumin, beta-2-microglobulin levels, and PCI percentages observed in the 2 groups. Conclusion: Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM.

KW - FDG-PET

KW - MIBI scintigraphy

KW - Multiple myeloma

UR - http://www.scopus.com/inward/record.url?scp=75149129097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75149129097&partnerID=8YFLogxK

U2 - 10.1097/RLU.0b013e3181c3619c

DO - 10.1097/RLU.0b013e3181c3619c

M3 - Article

VL - 35

SP - 1

EP - 5

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 1

ER -