The prognostic value of sleep patterns in disorders of consciousness in the sub-acute phase

Dario Arnaldi, Michele Terzaghi, Riccardo Cremascoli, Fabrizio De Carli, Giorgio Maggioni, Caterina Pistarini, Flavio Nobili, Arrigo Moglia, Raffaele Manni

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to evaluate, through polysomnographic analysis, the prognostic value of sleep patterns, compared to other prognostic factors, in patients with disorders of consciousness (DOCs) in the sub-acute phase. Methods: Twenty-seven patients underwent 24-polysomnography and clinical evaluation 3.5 ± 2 months after brain injury. Their clinical outcome was assessed 18.5 ± 9.9 months later. Polysomnographic recordings were evaluated using visual and quantitative indexes. A general linear model was applied to identify features able to predict clinical outcome. Clinical status at follow-up was analysed as a function of the baseline clinical status, the interval between brain injury and follow-up evaluation, patient age and gender, the aetiology of the injury, the lesion site, and visual and quantitative sleep indexes. Results: A better clinical outcome was predicted by a visual index indicating the presence of sleep integrity (p = 0.0006), a better baseline clinical status (p = 0.014), and younger age (p = 0.031). Addition of the quantitative sleep index strengthened the prediction. Conclusions: More structured sleep emerged as a valuable predictor of a positive clinical outcome in sub-acute DOC patients, even stronger than established predictors (e.g. age and baseline clinical condition). Significance: Both visual and quantitative sleep evaluation could be helpful in predicting clinical outcome in sub-acute DOCs.

Original languageEnglish
Pages (from-to)1445-1451
Number of pages7
JournalClinical Neurophysiology
Volume127
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Coma
  • EEG
  • Minimally conscious state
  • Sleep
  • Vegetative state

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Fingerprint Dive into the research topics of 'The prognostic value of sleep patterns in disorders of consciousness in the sub-acute phase'. Together they form a unique fingerprint.

Cite this