The prognostic value of the heart rate response during exercise and recovery in patients with heart failure: Influence of beta-blockade

Ross Arena, Jonathan Myers, Joshua Abella, Mary Ann Peberdy, Daniel Bensimhon, Paul Chase, Marco Guazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The heart rate increase during exercise (ΔHR) and heart rate recovery (HRR) have demonstrated prognostic value in several investigations, but its application in the heart failure (HF) population is limited, particularly in a beta-blocked (BB) cohort. Methods: Five-hundred and twenty subjects with HF underwent cardiopulmonary exercise testing to determine peak oxygen consumption (VO2), the minute ventilation/carbon dioxide production (VE/VCO2) slope, ΔHR and HRR at 1 min (HRR1). Results: There were 79 cardiac-related deaths during the tracking period. A HRR1 threshold of 1 was the strongest prognostic marker (chi-square: 39.9, p <0.001). The VE/VCO2 slope (residual chi-square: 21.8, p <0.001) and LVEF (residual chi-square: 9.6, p = 0.002) were also retained in the regression. Conclusions: These results indicate that HRR maintains prognostic value in HF irrespective of BB use. The routine inclusion of HRR in the prognostic assessment of patients with HF may be warranted.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalInternational Journal of Cardiology
Volume138
Issue number2
DOIs
Publication statusPublished - Jan 21 2010

Keywords

  • Exercise testing
  • Prognosis
  • Ventilatory expired gas

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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