The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer

Concetta Saponaro, Andrea Malfettone, Teresa Stefania Dell'Endice, Anna Elisabetta Brunetti, Patriciu Achimas-Cadariu, Angelo Paradiso, Anita Mangia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

NHERF1 (Na+/H+ exchanger regulatory factor) is a scaffolding protein, consists of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region. NHERF1 recruits macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues. It is involved in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors. Further, NHERF1 also linked other molecules involved in cell growth and cancer progression, such as PDGFR, PTEN, β-catenin, EGFR and HER2/neu. In this review, we focus on the role of NHERF1 during cancer development. Evidences of its involvement in cancer development are present in hepatocellular carcinoma, schwannoma, glioblastoma, colorectal cancer and particularly in breast cancer. Recent findings obtained from our laboratory show that cytoplasmic NHERF1 expression increases gradually in breast cancer during carcinogenesis, and its overexpression is associated with aggressive clinical parameters, unfavourable prognosis, and increased tumor hypoxia. Interestingly, also nuclear NHERF1 expression seems to play a role both in carcinogenesis and progression of colorectal cancer. These data suggest that NHERF1 could be a new biomarker of advanced malignancies.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalCancer Biomarkers
Volume14
Issue number2-3
DOIs
Publication statusPublished - 2014

Fingerprint

Neoplasms
Proteins
Colorectal Neoplasms
Carcinogenesis
Breast Neoplasms
PDZ Domains
Macromolecular Substances
Catenins
sodium-hydrogen exchanger regulatory factor
Neurilemmoma
Glioblastoma
G-Protein-Coupled Receptors
Hepatocellular Carcinoma
Epithelium
Biomarkers
Epithelial Cells
Ions
Membranes
Growth

Keywords

  • cancer progression
  • cancers
  • carcinogenesis
  • NHERF1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

Cite this

Saponaro, C., Malfettone, A., Dell'Endice, T. S., Brunetti, A. E., Achimas-Cadariu, P., Paradiso, A., & Mangia, A. (2014). The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer. Cancer Biomarkers, 14(2-3), 177-184. https://doi.org/10.3233/CBM-130329

The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer. / Saponaro, Concetta; Malfettone, Andrea; Dell'Endice, Teresa Stefania; Brunetti, Anna Elisabetta; Achimas-Cadariu, Patriciu; Paradiso, Angelo; Mangia, Anita.

In: Cancer Biomarkers, Vol. 14, No. 2-3, 2014, p. 177-184.

Research output: Contribution to journalArticle

Saponaro, C, Malfettone, A, Dell'Endice, TS, Brunetti, AE, Achimas-Cadariu, P, Paradiso, A & Mangia, A 2014, 'The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer', Cancer Biomarkers, vol. 14, no. 2-3, pp. 177-184. https://doi.org/10.3233/CBM-130329
Saponaro C, Malfettone A, Dell'Endice TS, Brunetti AE, Achimas-Cadariu P, Paradiso A et al. The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer. Cancer Biomarkers. 2014;14(2-3):177-184. https://doi.org/10.3233/CBM-130329
Saponaro, Concetta ; Malfettone, Andrea ; Dell'Endice, Teresa Stefania ; Brunetti, Anna Elisabetta ; Achimas-Cadariu, Patriciu ; Paradiso, Angelo ; Mangia, Anita. / The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer. In: Cancer Biomarkers. 2014 ; Vol. 14, No. 2-3. pp. 177-184.
@article{9bfdfafc5d714725a6f7eb722a2f84a6,
title = "The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer",
abstract = "NHERF1 (Na+/H+ exchanger regulatory factor) is a scaffolding protein, consists of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region. NHERF1 recruits macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues. It is involved in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors. Further, NHERF1 also linked other molecules involved in cell growth and cancer progression, such as PDGFR, PTEN, β-catenin, EGFR and HER2/neu. In this review, we focus on the role of NHERF1 during cancer development. Evidences of its involvement in cancer development are present in hepatocellular carcinoma, schwannoma, glioblastoma, colorectal cancer and particularly in breast cancer. Recent findings obtained from our laboratory show that cytoplasmic NHERF1 expression increases gradually in breast cancer during carcinogenesis, and its overexpression is associated with aggressive clinical parameters, unfavourable prognosis, and increased tumor hypoxia. Interestingly, also nuclear NHERF1 expression seems to play a role both in carcinogenesis and progression of colorectal cancer. These data suggest that NHERF1 could be a new biomarker of advanced malignancies.",
keywords = "cancer progression, cancers, carcinogenesis, NHERF1",
author = "Concetta Saponaro and Andrea Malfettone and Dell'Endice, {Teresa Stefania} and Brunetti, {Anna Elisabetta} and Patriciu Achimas-Cadariu and Angelo Paradiso and Anita Mangia",
year = "2014",
doi = "10.3233/CBM-130329",
language = "English",
volume = "14",
pages = "177--184",
journal = "Cancer Biomarkers",
issn = "1574-0153",
publisher = "IOS Press",
number = "2-3",

}

TY - JOUR

T1 - The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancer

AU - Saponaro, Concetta

AU - Malfettone, Andrea

AU - Dell'Endice, Teresa Stefania

AU - Brunetti, Anna Elisabetta

AU - Achimas-Cadariu, Patriciu

AU - Paradiso, Angelo

AU - Mangia, Anita

PY - 2014

Y1 - 2014

N2 - NHERF1 (Na+/H+ exchanger regulatory factor) is a scaffolding protein, consists of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region. NHERF1 recruits macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues. It is involved in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors. Further, NHERF1 also linked other molecules involved in cell growth and cancer progression, such as PDGFR, PTEN, β-catenin, EGFR and HER2/neu. In this review, we focus on the role of NHERF1 during cancer development. Evidences of its involvement in cancer development are present in hepatocellular carcinoma, schwannoma, glioblastoma, colorectal cancer and particularly in breast cancer. Recent findings obtained from our laboratory show that cytoplasmic NHERF1 expression increases gradually in breast cancer during carcinogenesis, and its overexpression is associated with aggressive clinical parameters, unfavourable prognosis, and increased tumor hypoxia. Interestingly, also nuclear NHERF1 expression seems to play a role both in carcinogenesis and progression of colorectal cancer. These data suggest that NHERF1 could be a new biomarker of advanced malignancies.

AB - NHERF1 (Na+/H+ exchanger regulatory factor) is a scaffolding protein, consists of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region. NHERF1 recruits macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues. It is involved in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors. Further, NHERF1 also linked other molecules involved in cell growth and cancer progression, such as PDGFR, PTEN, β-catenin, EGFR and HER2/neu. In this review, we focus on the role of NHERF1 during cancer development. Evidences of its involvement in cancer development are present in hepatocellular carcinoma, schwannoma, glioblastoma, colorectal cancer and particularly in breast cancer. Recent findings obtained from our laboratory show that cytoplasmic NHERF1 expression increases gradually in breast cancer during carcinogenesis, and its overexpression is associated with aggressive clinical parameters, unfavourable prognosis, and increased tumor hypoxia. Interestingly, also nuclear NHERF1 expression seems to play a role both in carcinogenesis and progression of colorectal cancer. These data suggest that NHERF1 could be a new biomarker of advanced malignancies.

KW - cancer progression

KW - cancers

KW - carcinogenesis

KW - NHERF1

UR - http://www.scopus.com/inward/record.url?scp=84904291430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904291430&partnerID=8YFLogxK

U2 - 10.3233/CBM-130329

DO - 10.3233/CBM-130329

M3 - Article

VL - 14

SP - 177

EP - 184

JO - Cancer Biomarkers

JF - Cancer Biomarkers

SN - 1574-0153

IS - 2-3

ER -