The progression of hemophilic arthropathy: The role of biomarkers

Gianluigi Pasta, Salvatore Annunziata, Alberto Polizzi, Laura Caliogna, Eugenio Jannelli, Alessandro Minen, Mario Mosconi, Francesco Benazzo, Matteo Nicola Dario Di Minno

Research output: Contribution to journalReview articlepeer-review


Background: Hemophilia A and B are X-linked congenital bleeding disorders characterized by recurrent hemarthroses leading to specific changes in the synovium and cartilage, which finally result in the destruction of the joint: this process is called hemophilic arthropathy (HA). This review highlights the most prominent molecular biomarkers found in the literature to discuss their potential use in the clinical practice to monitor bleeding, to assess the progression of the HA and the effectiveness of treatments. Methods: A review of the literature was performed on PubMed and Embase, from 3 to 7 August 2020. Study selection and data extraction were achieved independently by two authors and the following inclusion criteria were determined a priori: English language, available full text and articles published in peer-reviewed journal. In addition, further articles were identified by checking the bibliography of relevant articles and searching for the studies cited in all the articles examined. Results: Eligible studies obtained at the end of the search and screen process were seventy-three (73). Conclusions: Despite the surge of interest in the clinical use of biomarkers, current literature underlines the lack of their standardization and their potential use in the clinical practice preserving the role of physical examination and imaging in early diagnosis.

Original languageEnglish
Article number7292
Pages (from-to)1-20
Number of pages20
JournalInternational Journal of Molecular Sciences
Issue number19
Publication statusPublished - Oct 1 2020


  • Arthropathy
  • Biomarkers
  • Hemophilia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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