The prolonged cortical silent period in patients with Huntington's disease

N. Modugno, A. Currà, M. Giovannelli, A. Priori, F. Squitieri, S. Ruggieri, M. Manfredi, A. Berardelli

Research output: Contribution to journalArticle

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Abstract

Objectives: In a group of patients with Huntington's disease and age-matched controls, we studied the cortical silent period (SP) elicited by single transcranial magnetic stimulation (TMS) pulses. Methods: We measured the area of the pre-stimulus electromyographic (EMG) activity, the area of the motor evoked potentials (MEPs) and the duration of the SP induced by stimuli delivered at an intensity of 150% of motor threshold with a round coil placed over the vertex. We determined the cortical SP by sampling only the 5 traces containing the shortest SPs and by collecting 10 consecutive unselected traces without selecting trials. Results: Patients and controls had normal EMG background areas, and MEP latencies and areas. Whereas data measured from selected trials gave a normal duration of the SP (patients, 154 ± 58 ms; controls, 166 ± 22 ms), data from unselected trials yielded a significantly longer SP duration in patients than in controls (356 ± 251 vs. 159 ± 44 ms) and also a larger variance and range. Conclusions: We conclude that in Huntington's disease, an abnormal cortical SP is best sought by collecting unselected consecutive traces. We suggest that the prolonged SP in HD originates from a dysfunction of the mechanisms controlling the restart of voluntary movement after TMS.

Original languageEnglish
Pages (from-to)1470-1474
Number of pages5
JournalClinical Neurophysiology
Volume112
Issue number8
DOIs
Publication statusPublished - 2001

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Huntington Disease
Motor Evoked Potentials
Transcranial Magnetic Stimulation

Keywords

  • Chorea
  • Huntington's disease
  • Silent period
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

The prolonged cortical silent period in patients with Huntington's disease. / Modugno, N.; Currà, A.; Giovannelli, M.; Priori, A.; Squitieri, F.; Ruggieri, S.; Manfredi, M.; Berardelli, A.

In: Clinical Neurophysiology, Vol. 112, No. 8, 2001, p. 1470-1474.

Research output: Contribution to journalArticle

Modugno, N. ; Currà, A. ; Giovannelli, M. ; Priori, A. ; Squitieri, F. ; Ruggieri, S. ; Manfredi, M. ; Berardelli, A. / The prolonged cortical silent period in patients with Huntington's disease. In: Clinical Neurophysiology. 2001 ; Vol. 112, No. 8. pp. 1470-1474.
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AU - Currà, A.

AU - Giovannelli, M.

AU - Priori, A.

AU - Squitieri, F.

AU - Ruggieri, S.

AU - Manfredi, M.

AU - Berardelli, A.

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