The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep

C. Rostagno, G. F. Gensini, S. Boncinelli, M. Marsili, S. Castellani, P. Lorenzi, V. Merciai, M. Linden, G. L. Chelucci, F. Cresci

Research output: Contribution to journalArticlepeer-review

Abstract

The early increase of pulmonary artery pressure observed in different models of experimentally induced lung injury have been shown to be associated with the release of vasoconstrictive agents by activated platelets. The aim of this study was to evaluate the pattern of these metabolites, in particular TxA2, and the effects of the inhibition of their production by ASA on the modifications of pulmonary hemodynamics induced by oleic acid administration in sheep. Group I (8 sheep) was infused with oleic acid (0.09 ml/kg at 0.02 ml/min) while in group II (6 sheep ) ASA (10 mg/kg i.v.) was administered 30 minutes before oleic acid infusion. In group I pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) were significantly higher at the end of the infusion while cardiac output (CO) significantly decreased in comparison to baseline values. A marked increase in plasma TxB2 levels paralleled pulmonary hemodynamic changes. Also plasma 6 keto PGF levels increased after OA infusion. The early increase in PAP and PVR was significantly lower in group II (p1α . These results indicate that early pulmonary hypertension in oleic acid induced injury is mainly related to TxA2 released from platelets and leukocytes and that pulmonary hemodynamic changes are significantly inhibited by ASA pretreatment .

Original languageEnglish
Pages (from-to)35-45
Number of pages11
JournalThrombosis Research
Volume58
Issue number1
DOIs
Publication statusPublished - Apr 1 1990

Keywords

  • acetylsalicilic acid
  • arachidonic acid metabolites
  • lung injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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