TY - JOUR
T1 - The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus
AU - Restivo, Leonardo
AU - Roman, François
AU - Dumuis, Aline
AU - Bockaert, Joel
AU - Marchetti, Evelyne
AU - Ammassari-Teule, Martine
PY - 2008/9
Y1 - 2008/9
N2 - Pharmacological modulation of synaptic efficacy is a prominent target in the identification of promnesic compounds. Here, we report that pretraining administration of the serotonin 5-HT4 receptors (5-HT4Rs) partial agonist SL65.0155 enhances simultaneous olfactory discrimination performance and potentiates learning-induced dendritic spine growth in the mouse hippocampus. SL65.0155 does not affect spine density in the pseudo-trained mice and, by itself, does not promote spine growth. Injecting the 5-HT4 antagonist RS39604 prior to SL65.0155 prevents both the increase in performance and the additional formation of spines, thus confirming the 5-HT4Rs specificity of the observed effects. These findings provide evidence that 5-HT4Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits.
AB - Pharmacological modulation of synaptic efficacy is a prominent target in the identification of promnesic compounds. Here, we report that pretraining administration of the serotonin 5-HT4 receptors (5-HT4Rs) partial agonist SL65.0155 enhances simultaneous olfactory discrimination performance and potentiates learning-induced dendritic spine growth in the mouse hippocampus. SL65.0155 does not affect spine density in the pseudo-trained mice and, by itself, does not promote spine growth. Injecting the 5-HT4 antagonist RS39604 prior to SL65.0155 prevents both the increase in performance and the additional formation of spines, thus confirming the 5-HT4Rs specificity of the observed effects. These findings provide evidence that 5-HT4Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits.
KW - 5-HT receptor
KW - Dendritic spines
KW - Learning-induced structural plasticity
KW - Mice
KW - Olfactory discrimination
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U2 - 10.1038/sj.npp.1301644
DO - 10.1038/sj.npp.1301644
M3 - Article
C2 - 18075492
AN - SCOPUS:49549091142
VL - 33
SP - 2427
EP - 2434
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 10
ER -