The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus

Leonardo Restivo, François Roman, Aline Dumuis, Joel Bockaert, Evelyne Marchetti, Martine Ammassari-Teule

Research output: Contribution to journalArticle

Abstract

Pharmacological modulation of synaptic efficacy is a prominent target in the identification of promnesic compounds. Here, we report that pretraining administration of the serotonin 5-HT4 receptors (5-HT4Rs) partial agonist SL65.0155 enhances simultaneous olfactory discrimination performance and potentiates learning-induced dendritic spine growth in the mouse hippocampus. SL65.0155 does not affect spine density in the pseudo-trained mice and, by itself, does not promote spine growth. Injecting the 5-HT4 antagonist RS39604 prior to SL65.0155 prevents both the increase in performance and the additional formation of spines, thus confirming the 5-HT4Rs specificity of the observed effects. These findings provide evidence that 5-HT4Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits.

Original languageEnglish
Pages (from-to)2427-2434
Number of pages8
JournalNeuropsychopharmacology
Volume33
Issue number10
DOIs
Publication statusPublished - Sep 2008

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Keywords

  • 5-HT receptor
  • Dendritic spines
  • Learning-induced structural plasticity
  • Mice
  • Olfactory discrimination

ASJC Scopus subject areas

  • Pharmacology

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