The protean spectrum of non-Hodgkin lymphomas with prominent involvement of subcutaneous fat

Cesare Massone, Gian Piero Lozzi, Friederike Egberts, Regina Fink-Puches, Carlo Cota, Helmut Kerl, Lorenzo Cerroni

Research output: Contribution to journalArticlepeer-review


Background: Subcutaneous T-cell lymphoma (STCL) represents a controversial entity and a confused concept in the field of cutaneous T-cell lymphomas (CTCLs). Recently, α/β+/CD8+ STCL has been recognized by the new World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphomas as a distinct entity in the group of CTCLs. Observations: We reviewed a series of 53 biopsies from 26 patients (F: M = 19:7; median age: 48; range 18-87) of cutaneous B- and T-cell lymphomas characterized by prominent involvement of the subcutaneous tissue. We could classify our cases according to the following seven categories - (i) STCL: n = 16; (ii) extranodal NK/T-cell lymphoma, nasal type: n = 2; (iii) cutaneous γ/δ T-cell lymphoma: n = 2; (iv) anaplastic CD30+ large T-cell lymphoma: n = 1; (v) diffuse large B-cell lymphoma, secondary cutaneous: n = 3; (vi) lymphoplasmacytic lymphoma, secondary cutaneous: n = 1; (vii) specific cutaneous manifestations of myelogenous leukemia: n = 1. Conclusions: We demonstrated the protean nature of lymphomas with prominent involvement of the subcutaneous fat tissues. The term STCL should be restricted to a homogeneous group of cases characterized morphologically by an exclusive involvement of subcutaneous tissues, immunohistochemically by a T-cytotoxic α/β phenotype, and biologically by a relatively good prognosis.

Original languageEnglish
Pages (from-to)418-425
Number of pages8
JournalJournal of Cutaneous Pathology
Issue number6
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine


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