The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation

Vincenzo Mollace, Salvatore Ragusa, Iolanda Sacco, Carolina Muscoli, Francesca Sculco, Valeria Visalli, Ernesto Palma, Saverio Muscoli, Luigi Mondello, Paola Dugo, Domenicantonio Rotiroti, Francesco Romeo

Research output: Contribution to journalArticlepeer-review

Abstract

Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved.

Original languageEnglish
Pages (from-to)120-129
Number of pages10
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume13
Issue number2
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Balloon injury
  • Bergamot extract
  • Oxidative stress
  • OxyLDL

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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