The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid

Renata Alleva, Alessandra Scararmucci, Franco Mantero, Stefano Bompadre, Luciana Leoni, G. P. Littarru

Research output: Contribution to journalArticlepeer-review


Defective sperm function in infertile men has been associated with increased lipid peroxidation and impaired function of antioxidant defenses in spermatozoa. Evidence strongly suggests that CoQ10 a lipid-soluble component of the respiratory chain acts, in its reduced form (ubiquinol), as a potent antioxidant in various biological systems, such as lipoproteins and membranes. In this study we assayed CoQ10 content in both the reduced and oxidized form (ubiquinol/ubiquinone), and hydroperoxide levels in seminal plasma and seminal fluid from 32 subjects with a history of infertility. Our results showed a significant correlation between ubiquinol content and sperm count (r = 0.62; P <0.05) in seminal plasma. An inverse correlation between ubiquinol content and hydroperoxide levels both in seminal plasma and in seminal fluid (r= -0.56; P = 0.01) was found. Using multiple regression analysis we also found a strong correlation among sperm count, motility and ubiquinol-10 content (P <0.01) in seminal fluid. An inverse correlation between ubiquinol/ubiquinone ratio and percentage of abnormal morphology was also observed in total fluid. These results suggest that ubiquinol-10 inhibits hydroperoxide formation in seminal fluid and in seminal plasma. Since peroxidation in sperm cells is an important factor affecting male infertility, ubiquinol could assume a diagnostic and/or a therapeutic role in these patients.

Original languageEnglish
JournalMolecular Aspects of Medicine
Issue numberSUPPL.
Publication statusPublished - 1997


  • Hydroperoxides
  • Lipid peroxidation
  • Seminal fluid
  • Sperm motility
  • Ubiquinol-10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine


Dive into the research topics of 'The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid'. Together they form a unique fingerprint.

Cite this