The protein C pathway in intestinal barrier function: Challenging the hemostasis paradigm

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The protein C (PC) pathway is a well-characterized anticoagulant system. Produced mainly by the liver as a zymogen, PC is activated on the vascular endothelial cell surface by thrombin-thrombomodulin complex. Once activated, PC inactivates two important cofactors of the coagulation cascade, factors Va and VIIIa, which are crucial for thrombin generation. For many years, this pathway has been studied for the clotting process, but only recently great progress has been made in understanding other functions of the PC system. Indeed, much work demonstrates that this pathway exerts several activities not only involved in the coagulative process but also in inflammation, cell proliferation, apoptosis, stabilization of endothelial barrier, and fibrinolysis. In addition, a recent study has shed light on a new role of the PC system in controlling intestinal permeability function by regulating tight junction molecules and promoting mucosal healing. This review highlights these recent insights in the context of the complex pathogenesis of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1258
Issue number1
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Protein C
Hemostasis
Thrombin
Factor VIIIa
Factor Va
Thrombomodulin
Enzyme Precursors
Tight Junctions
Endothelial cells
Cell proliferation
Fibrinolysis
Coagulation
Inflammatory Bowel Diseases
Liver
Anticoagulants
Permeability
Endothelial Cells
Stabilization
Cell Proliferation
Protein

Keywords

  • Activated PC
  • Coagulation
  • Inflammatory bowel disease (IBD)
  • Intestinal barrier
  • Protein C

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

The protein C pathway in intestinal barrier function : Challenging the hemostasis paradigm. / D'Alessio, Silvia; Genua, Marco; Vetrano, Stefania.

In: Annals of the New York Academy of Sciences, Vol. 1258, No. 1, 07.2012, p. 78-85.

Research output: Contribution to journalArticle

@article{94fb1f9b2fb64a66947245282a4d8310,
title = "The protein C pathway in intestinal barrier function: Challenging the hemostasis paradigm",
abstract = "The protein C (PC) pathway is a well-characterized anticoagulant system. Produced mainly by the liver as a zymogen, PC is activated on the vascular endothelial cell surface by thrombin-thrombomodulin complex. Once activated, PC inactivates two important cofactors of the coagulation cascade, factors Va and VIIIa, which are crucial for thrombin generation. For many years, this pathway has been studied for the clotting process, but only recently great progress has been made in understanding other functions of the PC system. Indeed, much work demonstrates that this pathway exerts several activities not only involved in the coagulative process but also in inflammation, cell proliferation, apoptosis, stabilization of endothelial barrier, and fibrinolysis. In addition, a recent study has shed light on a new role of the PC system in controlling intestinal permeability function by regulating tight junction molecules and promoting mucosal healing. This review highlights these recent insights in the context of the complex pathogenesis of inflammatory bowel disease.",
keywords = "Activated PC, Coagulation, Inflammatory bowel disease (IBD), Intestinal barrier, Protein C",
author = "Silvia D'Alessio and Marco Genua and Stefania Vetrano",
year = "2012",
month = "7",
doi = "10.1111/j.1749-6632.2012.06557.x",
language = "English",
volume = "1258",
pages = "78--85",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The protein C pathway in intestinal barrier function

T2 - Challenging the hemostasis paradigm

AU - D'Alessio, Silvia

AU - Genua, Marco

AU - Vetrano, Stefania

PY - 2012/7

Y1 - 2012/7

N2 - The protein C (PC) pathway is a well-characterized anticoagulant system. Produced mainly by the liver as a zymogen, PC is activated on the vascular endothelial cell surface by thrombin-thrombomodulin complex. Once activated, PC inactivates two important cofactors of the coagulation cascade, factors Va and VIIIa, which are crucial for thrombin generation. For many years, this pathway has been studied for the clotting process, but only recently great progress has been made in understanding other functions of the PC system. Indeed, much work demonstrates that this pathway exerts several activities not only involved in the coagulative process but also in inflammation, cell proliferation, apoptosis, stabilization of endothelial barrier, and fibrinolysis. In addition, a recent study has shed light on a new role of the PC system in controlling intestinal permeability function by regulating tight junction molecules and promoting mucosal healing. This review highlights these recent insights in the context of the complex pathogenesis of inflammatory bowel disease.

AB - The protein C (PC) pathway is a well-characterized anticoagulant system. Produced mainly by the liver as a zymogen, PC is activated on the vascular endothelial cell surface by thrombin-thrombomodulin complex. Once activated, PC inactivates two important cofactors of the coagulation cascade, factors Va and VIIIa, which are crucial for thrombin generation. For many years, this pathway has been studied for the clotting process, but only recently great progress has been made in understanding other functions of the PC system. Indeed, much work demonstrates that this pathway exerts several activities not only involved in the coagulative process but also in inflammation, cell proliferation, apoptosis, stabilization of endothelial barrier, and fibrinolysis. In addition, a recent study has shed light on a new role of the PC system in controlling intestinal permeability function by regulating tight junction molecules and promoting mucosal healing. This review highlights these recent insights in the context of the complex pathogenesis of inflammatory bowel disease.

KW - Activated PC

KW - Coagulation

KW - Inflammatory bowel disease (IBD)

KW - Intestinal barrier

KW - Protein C

UR - http://www.scopus.com/inward/record.url?scp=84862847964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862847964&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2012.06557.x

DO - 10.1111/j.1749-6632.2012.06557.x

M3 - Article

C2 - 22731719

AN - SCOPUS:84862847964

VL - 1258

SP - 78

EP - 85

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

IS - 1

ER -