The protein C pathway in tissue inflammation and injury: Pathogenic role and therapeutic implications

Silvio Danese, Stefania Vetrano, Zhang Li, Victoria A. Poplis, Francis J. Castellino

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation and coagulation are closely linked interdependent processes. Under physiologic conditions, the tissue microcirculation functions in anticoagulant and anti-inflammatory fashions. However, when inflammation occurs, coagulation is also set in motion and actively participates in enhancing inflammation. Recently, novel and unexpected roles of hemostasis in the humoral and cellular components of innate immunity have been described. In particular, the protein C system, besides its well-recognized role in anticoagulation, plays a crucial role in inflammation. Indeed, the protein C system is now emerging as a novel participant in the pathogenesis of acute and chronic inflammatory diseases, such as sepsis, asthma, inflammatory bowel disease, atherosclerosis, and lung and heart inflammation, and may emerge as unexpected therapeutic targets for intervention.

Original languageEnglish
Pages (from-to)1121-1131
Number of pages11
JournalBlood
Volume115
Issue number6
DOIs
Publication statusPublished - Feb 11 2010

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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