The psoriasis genetics as a model of complex disease

Emiliano Giardina, Cecilia Sinibaldi, Giuseppe Novelli

Research output: Contribution to journalArticlepeer-review

Abstract

Psoriasis [OMIM*177900] is a common, chronic and papulosquamous inflammatory skin disease affecting approximately 2% of Caucasian. However, this disorder is rare among Japanese, Eskimos, West Africans and North American blacks and very uncommon in North American and South American natives. The causes for these variations are likely to be both genetic and environmental. Population-based studies and twin studies indicate that psoriasis is a heritable disease with a polygenic mode of inheritance with variable penetrance. Independent genome-wide scans have suggested the involvement of a large number of chromosomal regions (loci), and many candidate genes have been proposed. We discuss genetic approaches to the disease, results and interpretations of relevant studies, as well as future perspectives. Understanding the genetic basis of psoriasis will represent a major advance in our understanding of the disease and will reveal novel disease-specific biologic pathways.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalCurrent Drug Targets: Inflammation and Allergy
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Autoimmune-diseases
  • Complex diseases
  • HLA
  • Psoriasis
  • Psoriatic arthritis
  • Susceptibility to complex disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology
  • Immunology

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