TY - JOUR
T1 - The putative role of neuronal network synchronization as a potential biomarker for bipolar disorder
T2 - A review of EEG studies
AU - Maggioni, E.
AU - Bianchi, A. M.
AU - Altamura, A. C.
AU - Soares, Jair C.
AU - Brambilla, P.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Impaired intra-hemispheric and inter-hemispheric communication play a major role in the pathophysiology and cognitive disturbances of bipolar disorder (BD). Brain connectivity in BD has been largely investigated using magnetic resonance imaging (MRI) techniques, which have found alterations in prefronto-limbic coupling. In contrast, evidence for functional neural circuitry abnormalities in BD is less consistent. Indeed, just a few studies employing the electroencephalographic (EEG) technique, enabling the exploration of oscillatory brain dynamics, addressed this issue. Therefore, in the present review we summarize the results from EEG studies examining connectivity in patients with BD, to further clarify the putative role of neuronal network synchronization as a potential biomarker of this disabling mental illness.
AB - Impaired intra-hemispheric and inter-hemispheric communication play a major role in the pathophysiology and cognitive disturbances of bipolar disorder (BD). Brain connectivity in BD has been largely investigated using magnetic resonance imaging (MRI) techniques, which have found alterations in prefronto-limbic coupling. In contrast, evidence for functional neural circuitry abnormalities in BD is less consistent. Indeed, just a few studies employing the electroencephalographic (EEG) technique, enabling the exploration of oscillatory brain dynamics, addressed this issue. Therefore, in the present review we summarize the results from EEG studies examining connectivity in patients with BD, to further clarify the putative role of neuronal network synchronization as a potential biomarker of this disabling mental illness.
KW - Bipolar disorder
KW - Connectivity
KW - EEG
UR - http://www.scopus.com/inward/record.url?scp=85011022689&partnerID=8YFLogxK
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U2 - 10.1016/j.jad.2016.12.045
DO - 10.1016/j.jad.2016.12.045
M3 - Review article
AN - SCOPUS:85011022689
VL - 212
SP - 167
EP - 170
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -