The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites

Sabrina Prudente, Manisha Chandalia, Eleonora Morini, Roberto Baratta, Bruno Dallapiccola, Nicola Abate, Lucia Fzrittitta, Vincenzo Trischitta

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This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level 2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
Issue number1
Publication statusPublished - Jan 2007


  • BMI
  • Genetic susceptibility

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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