The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: A multidisciplinary vulcan team review

Luca Tagliaferri, Valentina Lancellotta, Calogero Casà, Simona Maria Fragomeni, Martina Ferioli, Stefano Gentileschi, Anna Amelia Caretto, Giacomo Corrado, Benedetta Gui, Giuseppe Ferdinando Colloca, Maria Antonietta Gambacorta, Alessio Giuseppe Morganti, Giorgia Garganese, Gabriella Macchia

Research output: Contribution to journalReview articlepeer-review

Abstract

Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.

Original languageEnglish
Article number5747
JournalCancers
Volume13
Issue number22
DOIs
Publication statusPublished - Nov 1 2021

Keywords

  • Radiotherapy
  • Review
  • Vulvar cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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