TY - JOUR
T1 - The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer
T2 - A multidisciplinary vulcan team review
AU - Tagliaferri, Luca
AU - Lancellotta, Valentina
AU - Casà, Calogero
AU - Fragomeni, Simona Maria
AU - Ferioli, Martina
AU - Gentileschi, Stefano
AU - Caretto, Anna Amelia
AU - Corrado, Giacomo
AU - Gui, Benedetta
AU - Colloca, Giuseppe Ferdinando
AU - Gambacorta, Maria Antonietta
AU - Morganti, Alessio Giuseppe
AU - Garganese, Giorgia
AU - Macchia, Gabriella
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
AB - Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
KW - Radiotherapy
KW - Review
KW - Vulvar cancer
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U2 - 10.3390/cancers13225747
DO - 10.3390/cancers13225747
M3 - Review article
AN - SCOPUS:85119078097
VL - 13
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 22
M1 - 5747
ER -