TY - JOUR
T1 - The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors
AU - Weinstein-Oppenheimer, Caroline R.
AU - Blalock, William L.
AU - Steelman, Linda S.
AU - Chang, Fumin
AU - McCubrey, James A.
PY - 2000
Y1 - 2000
N2 - This review focuses on the Ras-Raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signal transduction pathway and the consequences of its unregulation in the development of cancer. The roles of some of the cell membrane receptors involved in the activation of this pathway, the G-protein Ras, the Raf, MEK and ERK kinases, the phosphatases that regulate these kinases, as well as the downstream transcription factors that become activated, are discussed. The roles of the Ras-Raf-MEK-ERK pathway in the regulation of apoptosis and cell cycle progression are also analyzed. In addition, potential targets for pharmacological intervention in growth factor-responsive cells are evaluated.
AB - This review focuses on the Ras-Raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signal transduction pathway and the consequences of its unregulation in the development of cancer. The roles of some of the cell membrane receptors involved in the activation of this pathway, the G-protein Ras, the Raf, MEK and ERK kinases, the phosphatases that regulate these kinases, as well as the downstream transcription factors that become activated, are discussed. The roles of the Ras-Raf-MEK-ERK pathway in the regulation of apoptosis and cell cycle progression are also analyzed. In addition, potential targets for pharmacological intervention in growth factor-responsive cells are evaluated.
KW - ERK
KW - Growth factors
KW - MEK
KW - Raf
KW - Ras
KW - Receptors
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U2 - 10.1016/S0163-7258(00)00085-1
DO - 10.1016/S0163-7258(00)00085-1
M3 - Article
C2 - 11337027
AN - SCOPUS:0034450953
VL - 88
SP - 229
EP - 279
JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
SN - 0163-7258
IS - 3
ER -