The Rate of Secondary Malignancies After Radical Prostatectomy Versus External Beam Radiation Therapy for Localized Prostate Cancer: A Population-Based Study on 17,845 Patients

Naeem Bhojani, Umberto Capitanio, Nazareno Suardi, Claudio Jeldres, Hendrik Isbarn, Shahrokh F. Shariat, Markus Graefen, Philippe Arjane, Alain Duclos, Jean Baptiste Lattouf, Fred Saad, Luc Valiquette, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: External-beam radiation therapy (EBRT) may predispose to secondary malignancies that include bladder cancer (BCa), rectal cancer (RCa), and lung cancer (LCa). We tested this hypothesis in a large French Canadian population-based cohort of prostate cancer patients. Methods and Materials: Overall, 8,455 radical prostatectomy (RP) and 9,390 EBRT patients treated between 1983 and 2003 were assessed with Kaplan-Meier and Cox regression analyses. Three endpoints were examined: (1) diagnosis of secondary BCa, (2) LCa, or (3) RCa. Covariates included age, Charlson comorbidity index, and year of treatment. Results: In multivariable analyses that relied on incident cases diagnosed 60 months or later after RP or EBRT, the rates of BCa (hazard ratio [HR], 1.4; p = 0.02), LCa (HR, 2.0; p = 0.004), and RCa (HR 2.1; p

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume76
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

Keywords

  • Prostate cancer
  • Radical prostatectomy
  • radiotherapy
  • Secondary malignancies

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

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