The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment

Antonio Frega, Francesco Sopracordevole, Paolo Scirpa, Alberto Biamonti, Laura Lorenzon, Simona Scarani, Luana de Sanctis, Arianna Pacchiarotti, Massimo Moscarini, Deborah French

Research output: Contribution to journalArticle

Abstract

Background: VIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment. Material/Methods: The study enrolled 103 women affected by VIN usual type. They underwent wide local excision by CO 2 laser. The patients were investigated by clinical evaluation and HPV DNA test 6 months after surgical treatment, and then were followed-up at 12, 18, 24, and 36 months. The recurrences were treated with re-excision. Results: The rate of HPV infection after surgical treatment was 34% at 6 months, 36.9% at 12 months, 40% at 18 months, 41.7% at 24 months and 44.7% at 36 months. The mean time from HPV infection to the development of VIN was 18.8 months. Conclusions: HPV testing in the follow-up of VIN usual type patients might be useful for identifying those patients with a higher risk of recurrence after surgical treatment, although more studies are needed. These preliminary data suggest that the test, in addition to clinical examination, can improve the effcacy of the follow-up.

Original languageEnglish
JournalMedical Science Monitor
Volume17
Issue number9
Publication statusPublished - 2011

Keywords

  • HPV DNA test
  • Human papillomavirus (HPV)
  • VIN usual type

ASJC Scopus subject areas

  • Medicine(all)

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