La recidiva di epatite C nel trapianto ortotopico di fegato (OLT).

Translated title of the contribution: The recurrence of hepatitic C in orthotopic liver transplantation

M. R. Germi, R. Pellicci, R. Testa, G. Ardizzone, F. Lemut, A. Pozzo, C. Siani

Research output: Contribution to journalArticle

Abstract

BACKGROUND: This study is a review of hepatitis C recurrence in patients undergoing an orthotopic liver transplantation (OLT); to verify how many patients HCV-positive before OLT confirm a persistent viremia after OLT and how many with viremia show hepatitis histological evidence. METHODS: Thirty consecutive patients, 24 males, median age 52.5 underwent OLT for posthepatitic C cirrhosis since January 1993 in the "Transplantation Center" of Genoa. Serology included anti-HCV search, HCV-RNA and HBV-DNA determinations, biopses were performed in the transplanted liver within the month after operation, subsequently at every hepatic enzymes increase. RESULTS: Twenty-one patients are currently alive, median follow-up of 14.5 months. Before OLT anti-HCV antibodies search was positive in all the patients while the HCV-RNA by PCR resulted positive in 17 and negative in 4. Before OLT the HBV-DNA in patients with associated hepatitis B was negative. After OLT 5 patients, of the 17 HCV-RNA positive before OLT, have turned negative then all became again positive from 6 to 12 months later; 2 of the 4 patients HCV-RNA negative before OLT have turned positive, and remained still negative two with hepatitis C associated with hepatitis B. Although viral replication was present in 95% of the patients, clinical and histological evidence of recurrence was ascertained only in 29%. CONCLUSIONS: It should be noted that the hepatitis histological picture doesn't correspond to a severe worsening of clinical conditions, an evolution justifying transplantation. The long-term results of this therapeutic choice are still uncertain due to the high incidence of recurrences.

Translated title of the contributionThe recurrence of hepatitic C in orthotopic liver transplantation
Original languageItalian
Pages (from-to)29-33
Number of pages5
JournalMinerva Anestesiologica
Volume64
Issue number1-2
Publication statusPublished - Jan 1998

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Germi, M. R., Pellicci, R., Testa, R., Ardizzone, G., Lemut, F., Pozzo, A., & Siani, C. (1998). La recidiva di epatite C nel trapianto ortotopico di fegato (OLT). Minerva Anestesiologica, 64(1-2), 29-33.