MECCANISMI DI REGOLAZIONE DEL FLUSSO EMATICO CEREBRALE. PARTE 2: STUDIO SPERIMENTALE. CORRELAZIONI TRA PRESSIONE INTRACRANICA E VELOCITA DI FLUSSO EMATICO

Translated title of the contribution: The regulation of cerebral blood flow. Part two: Experimental study. Correlations between intracranial pressure and cerebral blood flow velocity

A. Rinaldi, C. Anile, G. Maira, G. Neri

Research output: Contribution to journalArticle

Abstract

Cerebral vasoregulation is a complex mechanism concerning the ability of the cerebrovascular system to maintain within certain limits a constant blood flow against physiologic or pathologic variations of the perfusion pressure and/or systemic metabolism. We discuss here two experimental models studying cerebral blood flow variations induced by intracranial hypertension. In both models basal parameters and intracranial pressure were monitored; synchronously we recorded Doppler flow velocity, at the level of internal carotid artery in the first model on the rabbit, at the level of the superior longitudinal sinus in the second model on the lamb. Pressure and flow trend has been followed during the stages of intracranial hypertension induced by intraventricular infusion up to intracranial circulatory arrest, as documented by Doppler flow velocity and electroencephalogram (brain tamponade). The results seem to confirm the validity of 1: the choice of the two models in evaluating the modifications occurring at different sites of the cerebro-vascular bed; 2: the crucial role of the predural venous section in conditioning the cerebral blood flow. Synchronous monitoring of the blood flow velocity at the internal carotid and superior longitudinal sinus seems to show the site and the mechanisms regulating the cerebral blood flow.

Original languageItalian
Pages (from-to)305-312
Number of pages8
JournalRivista di Neurobiologia
Volume40
Issue number4
Publication statusPublished - 1994

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Cerebrovascular Circulation
Blood Flow Velocity
Intracranial Pressure
Superior Sagittal Sinus
Intracranial Hypertension
Intraventricular Infusions
Pressure
Internal Carotid Artery
Blood Vessels
Electroencephalography
Theoretical Models
Perfusion
Rabbits
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "MECCANISMI DI REGOLAZIONE DEL FLUSSO EMATICO CEREBRALE. PARTE 2: STUDIO SPERIMENTALE. CORRELAZIONI TRA PRESSIONE INTRACRANICA E VELOCITA DI FLUSSO EMATICO",
abstract = "Cerebral vasoregulation is a complex mechanism concerning the ability of the cerebrovascular system to maintain within certain limits a constant blood flow against physiologic or pathologic variations of the perfusion pressure and/or systemic metabolism. We discuss here two experimental models studying cerebral blood flow variations induced by intracranial hypertension. In both models basal parameters and intracranial pressure were monitored; synchronously we recorded Doppler flow velocity, at the level of internal carotid artery in the first model on the rabbit, at the level of the superior longitudinal sinus in the second model on the lamb. Pressure and flow trend has been followed during the stages of intracranial hypertension induced by intraventricular infusion up to intracranial circulatory arrest, as documented by Doppler flow velocity and electroencephalogram (brain tamponade). The results seem to confirm the validity of 1: the choice of the two models in evaluating the modifications occurring at different sites of the cerebro-vascular bed; 2: the crucial role of the predural venous section in conditioning the cerebral blood flow. Synchronous monitoring of the blood flow velocity at the internal carotid and superior longitudinal sinus seems to show the site and the mechanisms regulating the cerebral blood flow.",
keywords = "brain tamponade, cerebral vasoregulation, Doppler velocitometry, intracranial hypertension",
author = "A. Rinaldi and C. Anile and G. Maira and G. Neri",
year = "1994",
language = "Italian",
volume = "40",
pages = "305--312",
journal = "Rivista Italiana di Neurobiologia",
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T1 - MECCANISMI DI REGOLAZIONE DEL FLUSSO EMATICO CEREBRALE. PARTE 2

T2 - STUDIO SPERIMENTALE. CORRELAZIONI TRA PRESSIONE INTRACRANICA E VELOCITA DI FLUSSO EMATICO

AU - Rinaldi, A.

AU - Anile, C.

AU - Maira, G.

AU - Neri, G.

PY - 1994

Y1 - 1994

N2 - Cerebral vasoregulation is a complex mechanism concerning the ability of the cerebrovascular system to maintain within certain limits a constant blood flow against physiologic or pathologic variations of the perfusion pressure and/or systemic metabolism. We discuss here two experimental models studying cerebral blood flow variations induced by intracranial hypertension. In both models basal parameters and intracranial pressure were monitored; synchronously we recorded Doppler flow velocity, at the level of internal carotid artery in the first model on the rabbit, at the level of the superior longitudinal sinus in the second model on the lamb. Pressure and flow trend has been followed during the stages of intracranial hypertension induced by intraventricular infusion up to intracranial circulatory arrest, as documented by Doppler flow velocity and electroencephalogram (brain tamponade). The results seem to confirm the validity of 1: the choice of the two models in evaluating the modifications occurring at different sites of the cerebro-vascular bed; 2: the crucial role of the predural venous section in conditioning the cerebral blood flow. Synchronous monitoring of the blood flow velocity at the internal carotid and superior longitudinal sinus seems to show the site and the mechanisms regulating the cerebral blood flow.

AB - Cerebral vasoregulation is a complex mechanism concerning the ability of the cerebrovascular system to maintain within certain limits a constant blood flow against physiologic or pathologic variations of the perfusion pressure and/or systemic metabolism. We discuss here two experimental models studying cerebral blood flow variations induced by intracranial hypertension. In both models basal parameters and intracranial pressure were monitored; synchronously we recorded Doppler flow velocity, at the level of internal carotid artery in the first model on the rabbit, at the level of the superior longitudinal sinus in the second model on the lamb. Pressure and flow trend has been followed during the stages of intracranial hypertension induced by intraventricular infusion up to intracranial circulatory arrest, as documented by Doppler flow velocity and electroencephalogram (brain tamponade). The results seem to confirm the validity of 1: the choice of the two models in evaluating the modifications occurring at different sites of the cerebro-vascular bed; 2: the crucial role of the predural venous section in conditioning the cerebral blood flow. Synchronous monitoring of the blood flow velocity at the internal carotid and superior longitudinal sinus seems to show the site and the mechanisms regulating the cerebral blood flow.

KW - brain tamponade

KW - cerebral vasoregulation

KW - Doppler velocitometry

KW - intracranial hypertension

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