Cerebral vasoregulation is a complex mechanism concerning the ability of the cerebrovascular system to maintain within certain limits a constant blood flow against physiologic or pathologic variations of the perfusion pressure and/or systemic metabolism. We discuss here two experimental models studying cerebral blood flow variations induced by intracranial hypertension. In both models basal parameters and intracranial pressure were monitored; synchronously we recorded Doppler flow velocity, at the level of internal carotid artery in the first model on the rabbit, at the level of the superior longitudinal sinus in the second model on the lamb. Pressure and flow trend has been followed during the stages of intracranial hypertension induced by intraventricular infusion up to intracranial circulatory arrest, as documented by Doppler flow velocity and electroencephalogram (brain tamponade). The results seem to confirm the validity of 1: the choice of the two models in evaluating the modifications occurring at different sites of the cerebro-vascular bed; 2: the crucial role of the predural venous section in conditioning the cerebral blood flow. Synchronous monitoring of the blood flow velocity at the internal carotid and superior longitudinal sinus seems to show the site and the mechanisms regulating the cerebral blood flow.
|Translated title of the contribution||The regulation of cerebral blood flow. Part two: Experimental study. Correlations between intracranial pressure and cerebral blood flow velocity|
|Number of pages||8|
|Journal||Rivista di Neurobiologia|
|Publication status||Published - 1994|
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